ChemInform Abstract: Practical Synthesis of Amides from Alkynyl Bromides, Amines, and Water.

Abstract

Practical Synthesis of Amides from Alkynyl Bromides, Amines, and Water. -Reaction of alkynyl bromides (I) and (IV) with primary or secondary amines (II) and (V) in aqueous solution provides an efficient access towards carboxylic amides in good yields. The method proceeds without the need for transition metal catalysts and organic solvents. Aniline (IIg) is not a suitable substrate. -(CHEN, Z.-W.; JIANG*, H.-F.; PAN, X.-Y.; HE, Z.-J.; Tetrahedron 67 (2011) 33, 5920-5927, http://dx.

Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl 2

“…for C 15 H 16 NO [M + H] + : 226.1232. Found 226.1230.1 H data were consistent with those reported in the literature[34]. 9H),6.09 (brs, 1H), 4.45-4.47 (d, J = 5.6 Hz, 2H), 3.88 (s, 2H); 13 C NMR (125 MHz, CDCl 3 ) δ 40.83, 43.77, 125.08, 127.43, 127.62 (2C), 128.39, 128.64 (2C), 130.30, 133.43, 133.54, 137.97, 148.85, 168.88; HR-MS (ESI + ) calcd.…”