ChemInform Abstract: Preparation of Optically Active 1,2‐Diol Monotosylates by Enzymatic Hydrolysis.

Abstract

Alcohols P 0110Preparation of Optically Active 1,2-Diol Monotosylates by Enzymatic Hydrolysis.-Lipase PS catalyzed hydrolysis of the acetates (I) proceeds with excellent enantioselectivity to afford the (S)-isomers and the enantiomeric alcohols. A unique temperature effect is observed and optimal results are obtained at 30°C. -(SHIMADA, Y.; SATO, H.; MINOWA, S.; MATSUMOTO*, K.; Synlett 2008, 3, 367-370; Dep. Chem., Meisei Univ., Hino, Tokyo 191, Japan; Eng.) -Mais 23-053