ChemInform Abstract: PREPARATION OF TRANS‐5‐HYDROXY‐L‐PIPECOLIC ACID AND CIS‐4‐HYDROXY‐L‐PIPECOLIC ACID FROM L‐BAIKIAIN (1,2,5,6‐L‐TETRAHYDROPYRIDINE‐2‐CARBOXYLIC ACID)

Abstract

ABSTRACT. 2-~-5-OH-L-pipecolic -acid together with Z-cis-4-0H-i-pipecolic acid is obtained in a 7 : 3 ratio by reduction of the oxymercuration product of Z-L-baikiain (Z-I,2,5,6-;-tetrahydropyridine-2-carboxylic acid).fluoroacetate, thus giving access to the preparation of either of the two isomers.The opposite composition ratio is obtained using mercuric tri-INTRODUCTION.

Asymmetric syntheses of pipecolic acid and derivatives

“…14) a natural unsaturated pipecolic acid derivative (Callens et al, 1982;Fujita et al, 1963;Hanson and Russell, 1989). …”

High‐performance liquid chromatographic enantioseparation of unusual secondary amino acids on a D‐penicillamine‐based chiral ligand exchange column

“…), cis-4-hydroxypiperidine-2-carboxylic acid (8, enantiopure (2S,4R) 17 ; racemic 19 ), trans-5-hydroxypiperidine-2-carboxylic acid (9, enantiopure (2S,5R) 17 ; racemic 20 ), cis-5-methylpiperazine-2-carboxylic acid (11, racemic 21 ), morpholine-3-carboxylic acid (12, enantiopure S…”