ChemInform Abstract: Pyridazine‐Fused Carbazoles: Synthesis, Reactivity, and Antitumor Activity.

Haider, N.

doi:10.1002/chin.200236281

Cited by 4 publications

(13 citation statements)

References 15 publications

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“…e structurally rigid carbazolyl ring is also found friendly towards the introduction of various functional groups. Carbazole nucleus has always stimulated the endeavors to �nd new pathways for its synthesis and its novel derivatives because of extensive photophysical, photochemical, and biological properties [7] especially their amazing pharmacological pro�le and their role as drug molecule [8]. To date, numerous researchers make efforts to develop efficient synthetic avenues to carbazole and its well-modi�ed derivatives, which are well documented [9,10].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles

Yaqub

Hannan

Akbar

et al. 2012

Journal of Chemistry

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Strategy to synthesize novel carbazole, that is, 2,3-dihydro-2-phenyl-6H-pyridazino[4, 5-b]carbazole-1,4-dione (2), is developed as key reaction. This novel compound showed ideal reactivity toward different functional groups like methyl, carboxylic, nitro, piperazine, and amine; thus series of its derivatives are synthesized sequentially with the aim to fuel up the carbazole compounds with new versatile derivatives. All compounds were investigated for their activity against bacteria (MRSA andS. typhi) and fungi (Candida albicans). Among tested compounds3,6, and8exhibited pronounced antibacterial activities while2,5, and9also showed moderate activities.2,3,5,7, and9showed stronger antifungal activity againstCandida albicanscomparable to positive control.

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Section: Introductionmentioning

confidence: 99%

“…Synthesis of 2,3,4,6-Tetrahydro-1,4-dioxo-2-phenyl-1Hpyridazino[4, 5-b]carbazole-8,9-dicarboxylic acid(8). Product 7 (3.55 gm, 0.01 mol) and excess of potassium ferricyanide solution in 0.5 M sodium hydroxide with few drops of pyridine were re�uxed for �ve hours at 200 ∘ C. e reaction mixture was cooled in ice bath to obtain solid product.…”

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confidence: 99%

Synthesis, Antibacterial, and Antifungal Activities of Novel Pyridazino Carbazoles

Yaqub

Hannan

Akbar

et al. 2012

Journal of Chemistry

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“…The discovery of the antineoplastic activity of the naturally occurring alkaloid ellipticine and its isomer olivacine Fig. (1) has stimulated considerable research efforts in the field of carbazole systems (13) . A variety of carbazoles and its annulated derivatives represent DNA ligands with pronounced antitumor activity (14) .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Study of New N-Substituted Carbazole as Some Antifungal Agents

Salih¹

2008

JNUS

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Carbazole (1) upon condensation with ethylchloroacetate followed by treatment with hydrazine hydrate yielded 2-(9H-carbazol-9-yl) acetohydrazide (3). Treatment of compound (3) with sodium nitrite resulted in the formation of diazonium salt (4). Reaction of (4) with ethylacetoacetate and acetylacetone afforded ethyl 2-[3-(9H-carbazol-9-ylacetyl) triazanylidene]-3-oxobutanoate ( 5) and 3-[3-(9H-carbazol-9-ylacetyl)triazanylidene] pentane-2,4-dione (6), respectively. Reaction of ( 5) and ( 6) with phenylhydrazine and urea yielded 4-[3-(9H-carbazol-9-ylacetyl)triazanylidene]-5methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one ( 7) and 5-[3-(9H-carbazol-9-ylacetyl) triazanylidene]-4,6-dimethylpyrimidin-2(5H)-one (8), respectively. The newly synthesized compounds were characterized by IR, 1 H-NMR and 13 C-NMR analysis. Potential antifungal effects of the synthesized compounds were investigated using the Candida albicans and Aspergillus niger strains. The newly synthesized compounds exhibited promising activities, particularly compounds (7, 8 and 9).

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“…Such functionalised tetracyclic pyridazines are of interest as aza analogues of the pyrido [4,3-b]carbazole alkaloids, ellipticine and olivacine [3][4][5] and related antitumor agents. The synthesis and anticancer activity of polycyclic nitrogen heterocycles of this and other types has been a major subject in our department's recent research activities [6][7][8][9][10][11].…”

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confidence: 99%