ChemInform Abstract: (R)‐Methanandamide: A Chiral Novel Anandamide Possessing Higher Potency and Metabolic Stability.

Abstract

hormones hormones U 1000 44 -220 (R)-Methanandamide: A Chiral Novel Anandamide Possessing Higher Potency and Metabolic Stability. -Four chiral analogues of anandamide are synthesized and evaluated for their receptor binding and pharmaceutical activities. Compound (IIIa) shows the best activity of all anandamide analogues reported to date. -(ABADJI, V.; LIN, S.; TAHA, G.; GRIFFIN, G.; STEVENSON, L. A.; PERTWEE, R. G.; MAKRIYANNIS, A.;

Cannabinoid signaling in health and disease

“…Peripherallyrestricted CB1 and CB2 agonist 6.1 27.9 (Dziadulewicz et al 2007) CP55940 CB1 and CB2 agonist 3.72 2.55 (Felder et al 1995) HU-210 CB1 and CB2 agonist 0.061 0.52 (Felder et al 1995) JWH015 CB1 and CB2 agonist 383 13.8 (Showalter et al 1996) JWH133 CB2-selective agonist 677 3.4 (Huffman et al 1999) Rmethanandamide CB1 and CB2 agonist 20 815 (Abadji et al 1994;Khanolkar et al 1996), THC CB1 and CB2 agonist 53.3 75.3 (Felder et al 1995) WIN55, 212-2 CB1 and CB2 agonist 3.3 62.3 (Felder et al 1995) Cannabinoid antagonists Description Ki for CB1 (nM)…”