ChemInform Abstract: REACTION OF 2,4‐DISUBSTITUTED CHLOROBENZENES WITH 3‐ALKYLAMINO AND 3‐DIALKYLAMINOPROPIONITRILES

Abstract

Die 2,4‐disubstituierten Chlorbenzole (Ia) bis (Id) reagieren mit Dimethylaminopropionitril (II), zum Teil in polaren Lösungsmitteln, zum Teil ohne Lösungsmittel, zu den N,N‐Dimethylanilinen (III).

An alternative synthetic route to the neuroleptic compound Pipothiazine

“…When sulfonyl chloride 2b was treated with dimethylamine in ethanol, a solid product was obtained: 4-chloro-N,N-dimethyl-3-nitrobenzenesulfonamide (2c) 13 along with a small amount of 4-(dimethylamino)-N,N-dimethyl-3-nitrobenzenesulfonamide (5) (Scheme 2). Both products 2c and 5 were separated by chromatography and characterized.…”