ChemInform Abstract: REACTION OF N‐ACYL‐β‐PHENYL‐β‐ALANINE PHENYLHYDRAZIDES WITH PHOSPHORYL CHLORIDE

Abstract

Beim Erhitzen der Phenylhydrazide (I) mit Phosphoroxychlorid in siedendem Methylenchlorid bilden sich unter Abspaltung von Nitrilen (III) die Indolderivate (II).

Divergent Syntheses of Isoquinolines and Indolo[1,2-a]quinazolines by Copper-Catalyzed Cascade Annulation from 2-Haloaryloxime Acetates with Active Methylene Compounds and Indoles

“…Similarly, indolo­[1,2- a ]­quinazoline derivatives represent an important nitrogen-containing tetracyclic motif in a variety of bioactive compounds, such as antitumor agents and protein kinase CK2 inhibitor (Scheme ). , To the best of our knowledge, the synthesis of functionalized indolo­[1,2- a ]­quinazolines is rarely reported. , Vidal described pioneering work on the synthesis of indolo­[1,2- a ]­quinazolines via intramolecular [3 + 2] cycloadditions of azido-ketenimines . Recently, Liu and Perumal developed a Cu catalytic system for the synthesis of indolo­[1,2- a ]­quinazolines. , However, the preparation of some practical and sensitive isoquinolines such as 4-cyanoisoquinoline and 3-aminoisoquinoline derivatives is one continuing challenge among general preparative methods, and the example of direct functionalization of indoles for the synthesis of indolo­[1,2- a ]­quinazoline derivatives has not been described.…”