ChemInform Abstract: Reactions of 1,4‐Dihydropyridines

Abstract

ChemInform Abstract (109 refs.).

CoFe2O4@SiO2‐CPTES‐Guanidine‐Cu(II): A novel and reusable nanocatalyst for the synthesis of 2,3‐dihydroquinazolin‐4(1H)‐ones and polyhydroquinolines and oxidation of sulfides

“…Heterocyclic compounds, especially those containing nitrogen, have attracted much attention in modern chemistry because these compounds play a key role in the fields of natural products, medicinal chemistry and materials chemistry. Polyhydroquinolines, as valuable and important compounds of N‐heterocycles, because of pharmacologic applications such as anti‐inflammatory, antibacterial, antidiabetic and antimalarial drugs and bronchodilators, have attracted much attention . Quinazolines are an important category of nitrogen‐containing heterocyclic compounds which consist of fused benzene and pyrimidine rings .…”

“…Polyhydroquinolines, as valuable and important compounds of N-heterocycles, because of pharmacologic applications such as anti-inflammatory, antibacterial, antidiabetic and antimalarial drugs and bronchodilators, have attracted much attention. [13,14] Quinazolines are an important category of nitrogencontaining heterocyclic compounds which consist of fused benzene and pyrimidine rings. [15] These compounds have significant biological activity such as antifungal, antitumour, vasodilatory, anticancer and antifibrilatory activities.…”

Synthesis of Stable Isotope Labeled 13C4-1,4-Dihydropyridines on 5,6-Position and Its Substituent Carbon

“…1,4-二氢吡啶类化合物是一种重要的氮杂环化合 物, 是重要生物学活性的基本结构原型 [1][2][3][4] . 许多 1,4-二 氢吡啶类化合物作为药剂被广泛使用, 例如用作抗惊厥 药、抗糖尿病药、抗焦虑药、抗抑郁药、抗肿瘤药、镇 痛药、镇静药、血管扩张药、支气管扩张药、催眠药、 抗炎药、神经保护药和神经肽 YY1 拮抗剂等 [5][6][7][8][9][10] . 硝苯 地平、尼莫地平、尼群地平、苯磺酸氨氯地平和马来酸 氨氯地平等 1,4-二氢吡啶是治疗心血管疾病的重要一类 钙通道阻滞剂 [11][12] , 手性 1,4-二氢吡啶是 NADH (Nicotinamide adenine dinucleotide) 辅 酶 的 类 似 物 , 也 是 NADH 的模拟物 [13][14] .…”