ChemInform Abstract: Reactions of 2‐Methyl‐ and 1,2‐Dimethyl‐1,4,5,6‐tetrahydropyrimidine with Aroyl Chlorides: Diverse Reactivities of Cyclic Ketene N,N′‐Acetals Generated in situ.

Abstract

Substrates (I) undergo Et3N-promoted reaction with aroyl chlorides to give N,N'-diaryl derivatives (III). The analogous 1,2-dimethyltetrahydropyrimidine (IV) yields trisaroyl compounds (V) with complete selectivity. -(YE, G.; CHATTERJEE, S.; ZHOU, A.; BARKER, B. L.; CHEN, C.; SONG, Y.; PITTMAN*, C. U.