ChemInform Abstract: Recent Advances in Microwave‐Assisted Organic Syntheses

Krstenansky, John L.; Cotterill, Ian C.

doi:10.1002/chin.200049266

Cited by 22 publications

(21 citation statements)

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“…The main benefits of performing the reaction under microwave conditions are the higher product yields and the significant rate-enhancements that can be observed. It’s clear that application of microwave technology to the rapid synthesis of potential biological molecules is a useful tool for the medicinal chemistry community, for whom reaction speed is of great importance [26,27]. Moreover, when a reaction is carried out in a microwave reactor, the use of solvent can be avoided [28,29], allowing eco-friendly synthesis and offering several advantages, such as reduced risk of explosions and easier work-up.…”

Section: Resultsmentioning

confidence: 99%

A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

et al. 2011

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Section: Resultsmentioning

confidence: 99%

A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

et al. 2011

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“…This choice was guided by the fact that the major benefits of performing reaction under microwave irradiation are higher product yields and significant rate enhancements compared to reactions which run with conventional heating (i.e., in oil bath). A real advantage of commercial laboratory microwave apparatus is their ability to control reaction conditions precisely, by monitoring reaction times and temperature/pressure (de la Hoz and Loupy, 2012;Bazureau and Draye, 2011;Krstenansky and Cotteril, 2000).…”

Section: Chemistrymentioning

confidence: 99%

Prospective study directed to the synthesis of unsymmetrical linked bis-5-arylidene rhodanine derivatives via “one-pot two steps” reactions under microwave irradiation with their antitumor activity

et al. 2014

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International audienceWe here report on the synthesis of new unsymmetrical linked bis-5-arylidene rhodanine derivatives with stereocontrolled Z-configuration. The 6 steps synthesis was achieved and the key steps are the construction of the two 5-arylidene rhodanine moieties using an “one-pot two-steps” method under microwave dielectric heating in a closed reactor. The intermediates 6, 7 and desired unsymmetrical compounds 9 have been also evaluated for their in vitro inhibition of cell proliferation (Huh7 D12, Caco2, MDA-MB 231, HCT116, and NCI-H727 tumoral cell lines). Two of all compounds have shown potent activity against Huh7 D12, Caco2, and MDA-MB 231

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“…The use of microwave irradiation synthetic method has recently gained much attention due to the fact that it speedily facilitates the synthesis of new chemical entities with pharmaceutical applications by improving the efficiency of such chemical reactions [1,2]. Isatin is a versatile precursor in fine organic/inorganic syntheses of many amine-, ether-, nitrile-and oxazolederivatives [3,4,5], as well as several metal complexes [6,7,8,9], with antimicrobial [10], antiviral, anti-inflammatory, analgesic [7,11] and anticonvulsant activities [12].…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted Synthesis, Characterization, Antimicrobial and Antioxidant Activities of 1-Benzyl-3-[(4-Methylphenyl)Imino]-Indolin-2-One and Its Co(II) Complex

Ikotun

Omolekan

2019

CSIJ

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Aims:To develop a simple, efficient microwave-assisted synthetic method to prepare 1-Benzyl-3-[(4-methylphenyl)imino]-indolin-2-one and its Co(II) complex, characterize and ascertain their biological significance. Place and Duration of Study: Methodology: N-benzylisatin and 4-methylaniline were microwave irradiated in acetic acid to give 1-Benzyl-3-[(4-methylphenyl)imino]-indolin-2-one (C 22 H 18 N 2 O, L; 58 %). L was microwave irradiated Ikotun and Omolekan; CSIJ, 28(1): 1-12, 2019; Article no.CSIJ.51225 2 with CoCl 2 .6H 2 O in ethanol to yield its Co(II) complex. L was characterized using 1 H-NMR, 13 C-NMR, IR and Electronic spectra analyses, exact mass and melting point. IR and Electronic Spectra analyses with melting point confirmed the Co(II) complex was formed. The in-vitro antimicrobial activities of L were evaluated against three gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Haemolytic Staphylococcus aureus), three gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli and Klebsiella sp.) and three fungi (Aspergillus niger, Trichoderma viride and Penicillium citrinum). The IC 50 of L and its Co(II) complex were carried out against DPPH, H 2 O 2 and NO radicals, as well as their reducing power abilities. Results: Antimicrobial studies revealed L was active against Pseudomonas aeruginosa with a high zone of inhibition (thrice that of tetracycline) and Penicillium citrinum. The IC 50 of L against DPPH, H 2 O 2 and NO radicals were 0.561 ± 0.02, 0.3 ± 0.01 and 0.53 ± 0.01 μg/ml respectively, while they were 0.200 ± 0.01, 0.9 ± 0.02 and 0.26± 0.03 μg/ml for Co(II) complex. Their reducing power abilities at IC 50 were 0.53 μg/ml (for L) and 0.6 ± 0.03 μg/ml (the complex). Conclusion: L was synthesized within 15 min and its Co(II) complex within 5 min. L showed good free radical scavenging activities and reducing power when compared with ascorbic acid, while its Co(II) complex even performed better. Original Research Article

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ChemInform Abstract: Recent Advances in Microwave‐Assisted Organic Syntheses

Cited by 22 publications

References 0 publications

A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

A Practical Approach to New (5Z) 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives

Prospective study directed to the synthesis of unsymmetrical linked bis-5-arylidene rhodanine derivatives via “one-pot two steps” reactions under microwave irradiation with their antitumor activity

Microwave-assisted Synthesis, Characterization, Antimicrobial and Antioxidant Activities of 1-Benzyl-3-[(4-Methylphenyl)Imino]-Indolin-2-One and Its Co(II) Complex

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