ChemInform Abstract: Recent Applications of Barbituric Acid in Multicomponent Reactions

Ziarani, Ghodsi Mohammadi; Aleali, Faezeh; Lashgari, Negar

doi:10.1002/chin.201629260

Cited by 1 publication

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“…A plausible mechanism for the synthesis of pyrido[2,3‐ d :6,5‐ d ′]dipyrimidine using BAIL@UiO‐66 as catalyst is depicted in Scheme . The results were experimentally examined together with those in the literature . It is likely that BAIL@UiO‐66 will act as a Brønsted acid and increase the electrophilicity of the carbonyl group on the isatin and barbituric acid by means of a strong coordinate bond.…”

Section: Resultsmentioning

confidence: 99%

Highly efficient and green approach for the synthesis of spirooxindole derivatives in the presence of novel Brønsted acidic ionic liquids incorporated in UiO‐66 nanocages

Mirhosseini‐Eshkevari

Ghasemzadeh

Esnaashari

2019

Applied Organom Chemis

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An efficient and green approach is reported for the rapid synthesis of spirocyclic 2-oxindole using triethylenediamine or imidazole Brønsted acidic ionic liquids supported in Zr metal-organic framework (TEDA/IMIZ-BAIL@UiO-66) as a novel, superior and retrievable heterogeneous catalyst under ultrasonic irradiation. Heterocyclic compounds including pyrido[2,3d:6,5-d′]dipyrimidines and indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidines were obtained by the one-pot condensation reaction of 6-amino-1,3-dimethyluracil, isatins and cyclic 1,3-diketone (barbituric acid or 1,3-indanedione). The reusability of the catalyst, low catalyst loading, short reaction times, excellent yields, simple work-up, and use of sonochemical procedure as a mild process and an alternative energy source are some of the advantages of this method. Furthermore, the novel heterogeneous nanocomposite was fully characterized using various techniques.

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Section: Resultsmentioning

confidence: 99%