ChemInform Abstract: Recent Work on the Synthesis of Phosphonate‐Containing, Bone‐Active Heterocycles.

Abstract

The diol ditosylates (I) undergo ring closure reaction with tetraisopropyl methylenebisphosphonate (II) in toluene to give the tetraisopropyl cycloalkane‐1,1‐bisphosphonates (III) which are hydrolyzed with hydrochloric acid to form the cycloalkane‐1,1‐bisphosphonic acids (IV).