ChemInform Abstract: Reductive Amination Promoted by Tributyltin Hydride.

Abstract

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Reductive Amination of Aldehydes and Ketones Under Heterogeneous and Solvent-Free Conditions Using Sodium-Borohydride and Silica-Gel–Supported Sulfuric Acid

“…However, use of excess reagent (up to five-fold) along with toxic cyanide as the by-product limits its wide applications. [5] To further improve the scope and selectivity in reductive amination reactions, several other reducing systems including Bu 3 SnH, [6] Bu 2 SnClH and Bu 2 SnIH, [7] phenylsilane-dibutyltin dichloride, [8] and decaborane [9] have been described. All these methods require stoichiometric or excess quantities of the hydrides, which are generally highly reactive and expensive.…”