ChemInform Abstract: Reversal of Diastereoselectivity in the Synthesis of Peptidomimetic 3‐Carboxamide‐1,4‐benzodiazepin‐5‐ones.

Abstract

Reversal of Diastereoselectivity in the Synthesis of Peptidomimetic 3-Carboxamide-1,4-benzodiazepin-5-ones. -Starting from azido-or nitrobenzoic acids (I), isocyanides (II), glyoxals (III), and chiral methylbenzyl amine (IV), both diastereomers of benzodiazepinones [(VI) and (VII)] can be synthesized with a reversal of diastereoselectivity using different cyclization. -(PERTEJO, P.; CORRES, N.; TORROBA, T.; GARCIA-VALVERDE*, M.; Org. Lett. 17 (2015) 3, 612-615, http://dx.