ChemInform Abstract: ROLLE VON PROSTAGLANDINEN UND CATECHOLAMINEN BEI DER ENTZUENDUNG UND IM WIRKUNGSMECHANISMUS VON ANTIPHLOGISTICA

Bekemeier, H; Giessler, A. J.; Hirschelmann, R

doi:10.1002/chin.197509471

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“…Earlier investigations [1,2] confirmed the edema inducing and permeability increasing effect of LPC and phospholipase A 2 after injection into the rat paw and skin, respectively. It was also shown that the inhibition by LPC of contractions of the isolated guinea-pig small intestine evoked by different agonists I3, 4] also applies to prostaglandin E z and PGH 2 as agonists [51.…”

Section: Introductionsupporting

confidence: 63%

“…Platelet-activating factor (PAF) is a potent mediator of inflammatory reactions which has been studied in various animal species and found to be generated following activation of rabbit basophils 11], polymorphonuclears and monocytes [2]. Its chemical structure has been recently elucidated [3, 41 and further evidence has been obtained documenting the identity between the synthetic compound 1-O-alkyl-2-acetyl-sn-3-glycerylphosphorylcholine and the native rabbit PAF.…”

Section: Introductionmentioning

confidence: 98%

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Effect of lysolecithin on blood vessel reactivity and of some ethers and esters of glycerophosphocholine and phosphocholine, respectively, on aggregation of rat platelets

et al. 1981

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Infusion of lysolecithin (LPC; e.g. 88 microgram/ml for 0.5-1.0 min) did not significantly impair the vasopressor action of norepinephrine (NE), prostaglandin F2 alpha (PGF2 alpha) and extract of posterior pituitary (EPP) in the isolated perfused hind legs of rats. In other words, vascular smooth muscle behaves differently from the smooth muscle of the guinea-pig small intestine, since, in the latter, contractions evoked by acetylcholine, prostaglandins etc., are inhibited by LPC. Triton X 100 which, by comparison, was used as a detergent effective on the guinea-pig small intestine, depressed the vasopressor effect of NE, PGF2 alpha and EPP. LPC, at low concentrations (40 mumol/l), potentiated (15% max.) ADP-induced platelet aggregation (PA) in rat PRP but, at high concentrations, inhibited PA (IC50 = 390 mumol/l). 2-Hexadecylglycerophosphocholine and its short-chain 1-alkyl ethers, which are structurally related to platelet-activating factor, as well as some long-chain alkanol phosphocholine esters, were somewhat more active than LPC. Dipalmitoyllecithin (4-700 mumol/l) was without any effect.

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Section: Introductionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 98%