ChemInform Abstract: Samarium Diiodide‐Induced Radical Cyclization of Oxime Ether Connected with Formyl Group: Synthesis of 4‐Pyrimidinyl‐ and 4‐Purinylpyrrolidin‐3‐ol Nucleoside Analogues.

Abstract

Samarium Diiodide-Induced Radical Cyclization of Oxime Ether Connected with Formyl Group: Synthesis of 4-Pyrimidinyl-and 4-Purinylpyrrolidin-3-ol Nucleoside Analogues.-The title reaction is an efficient method to prepare 5-membered cyclic compounds bearing hydroxyl and amino groups with high stereoselectivity. It is successfully applied to the synthesis of the novel nucleoside analogues (VI) and (XI) which are of biological interest. -(MIYABE, H.; KANEHIRA, S.; KUME, K.; KANDORI, H.; NAITO, T.; Tetrahedron 54 (1998) 22, 5883-5892; Kobe Pharm. Univ., Higashinada, Kobe 658, Japan; EN)