ChemInform Abstract: Sannamycin‐Type Aminoglycoside Antibiotics — Efficient Syntheses — Biological Activity.

Abstract

Sannamycin-Type Aminoglycoside Antibiotics -Efficient Syntheses -Biological Activity.-Efficient syntheses of title compounds (IV) are developed based on glycosylations of the proven sannamycin-type acceptor (I) with glycosyl donors featuring novel protection patterns. Compounds (IVc,d) are screened for antibacterial activity. (IVd) exhibits modest activity, while (IVc) is found to be inactive. -(ERBECK, S.; LIANG, X.; HUNKLER, D.; KRIEGER, R.; PRINZBACH, H.; Eur.