ChemInform Abstract: Secondary Metabolites from the Genus Xylaria and Their Bioactivities

Song, Fei; Wu, Shao‐Hua; Zhai, Ying-Zhe; Xuan, Qi-Cun; Wang, Tang

doi:10.1002/chin.201430235

Cited by 12 publications

(12 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, few studies conducted on the active metabolites of Neofusicoccum parvum, and its antioxidant activity accounted for the highest proportion in the current study, which has never been reported in previous studies [99,100]. Besides, Xylaria species are widely distributed on the temperate to the tropical zones in the terrestrial globe, and fungi of this genus have been proved to be potential sources of novel secondary metabolites, and many of them have biological activities related to drug discovery, including cytotoxic, antimalarial, and antimicrobial activities [101]. In terms of bioactivity, active extracts of DS16-1 (Phomopsis sp.…”

Section: Discussionsupporting

confidence: 43%

Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir

Duan

Qin

et al. 2019

Preprint

View full text Add to dashboard Cite

Background The present study focuses on diversity and biological activities of the endophytic fungal community from Distylium chinense , a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir. This study has been explored the characteristics of endophytic fungi in waterlogged environment including both aquatic and terrestrial fungi, and they may produce new metabolites under complex and extreme conditions, which may possess bioactive property. Therefore, the antioxidant, antimicrobial and anticancer activities of all endophytes isolated from this study have been investigated. Moreover, the active metabolites of the most broad-spectrum bioactive strain have also been studied.Results A total of 154 fungal endophytes were isolated from roots and stems. They were categorized into 30 morphotypes based on cultural characteristics and were affiliated with 27 different taxa. Among these, the most abundant fungal orders included Diaporthales (34.4%) and Botryosphaeriales (30.5%), which were predominantly represented by the species Phomopsis sp. (24.7%) and Neofusicoccum parvum (23.4%). Fermentation extracts were evaluated, screening for antioxidant, antimicrobial and anticancer activities. Among the 154 isolates tested, 99 (64.3%) displayed significant antioxidant activity, 153 (99.4%) exhibited inclusive antimicrobial activity against at least one tested microorganism and 27 (17.5%) showed exclusive anticancer activity against one or more cancer cell lines. Specifically, the crude extract of Irpex lacteus DR10-1 exhibited note-worthy bioactivities. Further chemical investigation on DR10-1 strain resulted in the isolation and identification of two known bioactive metabolites, indole-3-carboxylic acid ( 1 ) and indole-3-carboxaldehyde ( 2 ), indicating their potential roles in plant growth promotion and human medicinal value.Conclusions These results indicated that diverse endophytic fungal population inhabits D. chinense . The isolated endophyte DR10-1 ( Irpex lacteus ) has the potential to be a source of novel antioxidant/antimicrobial/anticancer compounds. The findings of the present study not only provide a sustainable resource for the utilization of endophytic fungi in D. chinense but also provides an important basis for further understanding of fungal communities in medicinal plants.

show abstract

Section: Discussionsupporting

confidence: 43%

Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir

Duan

Qin

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…However, few studies conducted on the active metabolites of Neofusicoccum parvum, and its antioxidant activity accounted for the highest proportion in the current study, which has never been reported in previous studies [100,101]. Besides, Xylaria species are widely distributed on the temperate to the tropical zones in the terrestrial globe, and fungi of this genus have been proved to be potential sources of novel secondary metabolites, and many of them have biological activities related to drug discovery, including cytotoxic, antimalarial, and antimicrobial activities [102]. μg/mL [103].…”

Section: Bioactivity Evaluation Of Fungal Endophytessupporting

confidence: 43%

Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir

Duan

Qin

et al. 2019

Preprint

View full text Add to dashboard Cite

Background The present study involves diversity and biological activities of the endophytic fungal community from Distylium chinense , a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir. This study has been conducted hypothesizing that the microbial communities in the TGR area would contribute to the host plant tolerating a range of abiotic stress such as summer flooding, infertility, drought, salinity and soil erosion etc., and they may produce new metabolites, which may possess plentiful bioactive property, especially antioxidant activity. Therefore in the current study, the antioxidant, antimicrobial and anticancer activities of 154 endophytes recovered from D. chinense have been investigated. Furthermore, the active metabolites of the most broad-spectrum bioactive strain have also been studied.Results A total of 154 fungal endophytes were isolated from roots and stems. They were categorized into 30 morphotypes based on cultural characteristics and were affiliated with 27 different taxa. Among these, the most abundant fungal orders included Diaporthales (34.4%) and Botryosphaeriales (30.5%), which were predominantly represented by the species Phomopsis sp. (24.7%) and Neofusicoccum parvum (23.4%). Fermentation extracts were evaluated, screening for antioxidant, antimicrobial and anticancer activities. Among the 154 isolates tested, 99 (64.3%) displayed significant antioxidant activity, 153 (99.4%) exhibited inclusive antimicrobial activity against at least one tested microorganism and 27 (17.5%) showed exclusive anticancer activity against one or more cancer cell lines. Specifically, the crude extract of Irpex lacteus DR10-1 exhibited note-worthy bioactivities. Further chemical investigation on DR10-1 strain resulted in the isolation and identification of two known bioactive metabolites, indole-3-carboxylic acid ( 1 ) and indole-3-carboxaldehyde ( 2 ), indicating their potential roles in plant growth promotion and human medicinal value.Conclusion These results indicated that diverse endophytic fungal population inhabits D. chinense . One of the fungal isolate DR10-1 ( Irpex lacteus ) exhibited significant antioxidant, antimicrobial and anticancer potential. Further, its active secondary metabolites 1 and 2 also showed antioxidant, antimicrobial and anticancer potential.

show abstract

“…49 Cytochalasin E was identified as the most active component in brine shrimp toxicity and phytotoxicity potency in the fungal endophyte. The preliminary SAR analysis suggested that cytochalasin E with a characteristic 13-membered macrocyclic vinyl carbonate group could most likely result in strong activity.…”

Section: H− 1 H Cosy and Hmbc Correlations As Shown Inmentioning

confidence: 99%

Characterization of Cytochalasins from the Endophytic Xylaria sp. and Their Biological Functions

Zhang

Xiao

Sun

et al. 2014

J. Agric. Food Chem.

View full text Add to dashboard Cite

Bioassay-guided fractionation of the fermentation extract of Xylaria sp. XC-16, an endophyte from Toona sinensis led to the isolation of two new cytochalasans cytochalasin Z27, 1, and cytochalasin Z28, 2, along with three known compounds seco-cytochalasin E, 3, and cytochalasin Z18, 4, and cytochalasin E, 5. The structures of 1 and 2 were elucidated by spectroscopic and electronic circular dichroism methods. Compound 5 was shown to be potently cytotoxic against brine shrimp (LC50 = 2.79 μM), comparable to that of the positive agent toosendanin (LC50 = 4.03 μM), and also exhibited potential phytotoxic effects on Lactuca sativa and Raphanus sativus L. seedlings, which are higher than that of the positive control glyphosate. Additionally, the fungicidal effect of 2 against the phytopathogen Gibberella saubinetti was better than that of hymexazol. This is the first report of the three types of cytochalasins present in genus Xylaria. A structure-phytotoxicity activity relationship is also discussed.

show abstract

ChemInform Abstract: Secondary Metabolites from the Genus Xylaria and Their Bioactivities

Abstract: Review: 64 refs.

Cited by 12 publications

References 42 publications

Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir

Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir

Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir

Characterization of Cytochalasins from the Endophytic Xylaria sp. and Their Biological Functions

Contact Info

Product

Resources

About