ChemInform Abstract: Selective Substitution Reactions of Methoxycarbonylamino‐1‐(1‐benzotriazolyl)alkanes with Active Methylene Compounds.

Abstract

Selective Substitution Reactions of Methoxycarbonylamino-1-(1-benzotriazolyl)alkanes with Active Methylene Compounds. -The leaving tendency of either methoxycarbonylamino or benzotriazole group by treatment of adducts (IV) with active methylene compounds (V) is studied. In the presence of the Lewis acid SmI3, -NH-E takes priority over -Btz in the leaving process, whereas -Btz is preferentially substituted in the presence of sodium methylate as base. In the first process, electron--withdrawing groups lead to rapid decomposition of precursor (IV) and no product (VI) is obtained. -(ZHOU, L.; LV, X.; MAO, H.; WANG*, X.; J. Heterocycl. Chem. 48 (2011) 2, 434-440, http://dx.