ChemInform Abstract: Single Molecule Sensing with Solid‐State Nanopores: Novel Materials, Methods, and Applications

Abstract

Review: 68 refs.

Synchronized Optical and Electronic Detection of Biomolecules Using a Low Noise Nanopore Platform

“…[2][3][4][5] Recently, the desire to acquire complementary information, increase structural resolution and analytical throughput has led to the integration of additional detection methods such as transverse electrodes and optical detection via Raman and fluorescence spectroscopy. [6][7][8][9] The integration of fluorescence spectroscopy is of particular value due to its versatility: a range of molecular properties can be probed including molecular distance (via FRET), orientation (via polarization) and local environment (via quenching). 10 In addition, the nanopore platform provides the potential to enhance optical detection via control of throughput, incorporation of additional photonic structure or use as a zero-mode waveguide.…”