ChemInform Abstract: SNA‐8073‐B, a New Isotetracenone Antibiotic Inhibits Prolyl Endopeptidase. Part 1. Fermentation, Isolation and Biological Properties.

A major histopathological hallmark of Alzheimer's disease (AD) is the presence of amyloid deposits in the parenchyma of the amygdala, hippocampus, and neocortex1}. The principal component of the amyloid is the /3-amyloid protein (A/?), a 39-43 amino acid peptide composedof a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP)2). The neurotoxicity of the A/3 has been detected in several cell systems, including primary cultured neurons3). The A/3 having an alanine C-terminus is derived from the proteolytic cleavage of the APPby the action of the yet unidentified endoproteolytic enzymes, /3-and y-secretase4). Recent studies have suggested that prolyl endopeptidase could be involved in the processing of the C-terminal portion of the APP in AD5). The prolyl endopeptidase [PEP; EC 3.4.21,26] is a serine protease, which is known to cleave peptide substrates in the C-terminal side of proline residues6). It plays an important role in degradation of the proline-containing neuropeptides such as oxytocin, vasopressin, substance P, neurotensin and angiotensin, which were suggested to participate in learning and memory processes7'8-*. It was found that the PEP

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

ChemInform Abstract: SNA‐8073‐B, a New Isotetracenone Antibiotic Inhibits Prolyl Endopeptidase. Part 1. Fermentation, Isolation and Biological Properties.

Cited by 2 publications

References 1 publication

Polyozellin, a New Inhibitor of Prolyl Endopeptidase from Polyozellus multiplex.

Polyozellin, a New Inhibitor of Prolyl Endopeptidase from Polyozellus multiplex.

Kynapcin-12, a New p-Terphenyl Derivative from Polyozellus multiplex, Inhibits Prolyl Endopeptidase.

Contact Info

Product

Resources

About