ChemInform Abstract: Sonogashira Couplings of Aryl Bromides: Room Temperature, Water Only, No Copper.

Abstract

Alkynes Q 0087 Sonogashira Couplings of Aryl Bromides: Room Temperature, Water Only, No Copper. -With PTS as the nanomicelle-forming agent, the title reaction proceeds in pure water. A broad spectrum of water-insoluble aryl bromides and alkynes can be transformed without the use of any organic solvent or copper salts. -(LIPSHUTZ*, B. H.; CHUNG, D. W.; RICH, B.; Org. Lett. 10 (2008) 17, 3793-3796; Dep. Chem. Biochem., Univ. Calif., Santa Barbara, CA 93106, USA; Eng.) -R. Simon 02-075