ChemInform Abstract: State of the Art in the Synthesis of Complex Natural Marine Peptides

Alberício, Fernando; Álvarez, Mercedes; Bruno, P; Cañedo, Librada M.; Cuevas, Carmen; Francesch, Andrés; García-Ramos, Yésica; Just, Xavier; Martín, Jesús; Munt, Simon; A.-L., et A.-L. et

doi:10.1002/chin.201502256

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The close naturally occurring cyclopeptides exhibit potent biological activities, including insecticidal, antimicrobial, antifungal, and antiproliferative. They are produced by marine organisms and plants . A subgroup of this class of natural compounds is the cyclodipeptides, also known as 2,5-diketopiperazines, which showed various biological activities and displayed strong resistance against enzymatic hydrolysis, thus attracting great interest in a variety of fields spanning from functional materials to drug discovery …”

Section: Introductionmentioning

confidence: 99%

Bacterial Lipodepsipeptides and Some of Their Derivatives and Cyclic Dipeptides as Potential Agents for Biocontrol of Pathogenic Bacteria and Fungi of Agrarian Plants

Castaldi

Cimmino

Masi

2022

J. Agric. Food Chem.

View full text Add to dashboard Cite

Biotic stresses (fungi, bacteria, insects, weeds, etc.) are some of the most important causes of the decrease in the quality and quantity of crops that could become an emergency due to a noteworthy increase in the world population. Thus, to overcome these problems, massive use of chemical pesticides has been carried out with heavy consequences for environmental pollution and food safety. An eco-friendly alternative can be using natural compound-based biopesticides with high efficacy and selectivity. Some bacterial lipodepsipeptides (tolaasins I, II, A, D, and E and WLIP together with hexacetyl- and tetrahydro-tolaasin I and WLIP methyl ester) and cyclic dipeptides (cyclo( l -Pro- l -Tyr), cyclo( d -Pro- l -Tyr), cyclo( l -Pro- l -Val), and cyclo( l -Pro- l -Leu)) were assayed against several pathogenic bacteria and fungi of important agrarian plants. Lipodepsipeptides showed strong growth inhibition of all microorganisms tested in the range of 0.1–0.8 μg/mL, while cyclodipeptides, despite preserving this ability, showed a noteworthily reduced antimicrobial activity being active only in the range of 15–900 μg/mL. Among the lipodepsipeptides and cyclic dipeptides assayed, tolaasin d and cyclo( l -Pro- l -Tyr) (also named maculosin-1) appeared to be the most toxic compounds. Some structure–activity relationships of lipodepsipeptides were also discussed along with their practical application as biopesticides in agriculture.

show abstract

Section: Introductionmentioning

confidence: 99%