ChemInform Abstract: Stereochemical Control on the Michael Addition of Chiral 1,3‐Oxazolidine‐2‐thiones to N‐Crotonyl 1,3‐Oxazolidin‐2‐ones.

Abstract

Stereochemical Control on the Michael Addition of Chiral 1,3-Oxazolidine--2-thiones to N-Crotonyl 1,3-Oxazolidin-2-ones. -Conjugated addition of nonchiral oxazolidinethione (II) to chiral N-crotonyl oxazolidinones proceeds with poor diastereoselectivity. However, chiral substrates show excellent diastereoselectivities in the case of achiral Michael acceptor (V) or for matched pairs. -(MUNIVE, L.; DZAKUMA, S. A.; OLIVIO*, H. F.; Tetrahedron Lett. 54 (2013) 10, 1230-1232, http://dx.