ChemInform Abstract: Stereodivergent Synthesis of Enantioenriched 4‐Hydroxy‐2‐cyclopentenones.

Abstract

Stereodivergent Synthesis of Enantioenriched 4-Hydroxy-2-cyclopentenones. -Using a known pathway, chiral diol (II) can be easily obtained via Noyori reduction which establishes the product stereochemistry in a single step. Following ring-closing metathesis and simple oxidation give access to enantiomerically pure 4-hydroxycyclopentenones (4-HCPs) as valuable building blocks for further syntheses. -(SINGH, G.; MEYER, A.; AUBE*, J.; J. Org. Chem. 79 (2014) 1, 452-458, http://dx.