ChemInform Abstract: Stereoselective Synthesis of Arylglycine Derivatives via Palladium‐Catalyzed α‐Arylation of a Chiral Nickel(II) Glycinate.

Abstract

Stereoselective Synthesis of Arylglycine Derivatives via Palladium-Catalyzed -Arylation of a Chiral Nickel(II) Glycinate. -Structurally diverse aryl bromides are well tolerated in the -arylation reaction with a chiral nickel(II) glycinate complex. The diastereoisomerically pure nickel(II) arylglycine complexes can be converted to non-naturally occurring arylglycines in high yields and enantiomeric excess. The chiral auxiliary can be recovered and reused. -(ZHANG, F.; SUN, H.; SONG, Z.; ZHOU, S.; WEN, X.; XU, Q.-L.; SUN*, H.; J. Org. Chem. 80 (2015) 9, 4459-4464, http://dx.doi.org/10.