ChemInform Abstract: Stereoselectivity of the Antidopaminergic Effect of the Methyl Ester of N‐Caproylprolyltyrosine (I) — a Tripeptide Analogue of Neurotensin.

Abstract

Stereoselectivity of the Antidopaminergic Effect of the Methyl Ester of N-Caproylprolyltyrosine (I) -a Tripeptide Analogue of Neurotensin.-It is shown, that for an optimal antidopaminergic effect both amino acid residues of the title N-caproylprolyltyrosine (I) must have L-configuration. Changing one of the amino acids by its D-enantiomer results in loss of activity. N-Caproylprolyltyrosine containing D-prolyl and D-tyrosyl residues has a "pro-dopamine" effect. -(ZAITSEVA, N. I.; GUBASHEVA, T. A.; BRILING, V. K.; GUZEVATYKH, L. S.; OSTROVSKAYA, R. U.; VORONINA, T. A.; SEREDENIN, S. B.; Khim.-Farm. Zh. 34 (2000) 8, 20-22; Nauchno-issled. inst. farmakol. Ross. Akad. med. nauk, Moskva 125315, Russia; RU)