ChemInform Abstract: Studies Directed Towards the Synthesis of Immunosuppressive Agent FK‐ 506: Synthesis of the Entire Top‐Half.

Rao, A. V. Rama; Chakraborty, Tushar Kanti; Sankaranarayanan, Dhivya; Purandare, A. V.

doi:10.1002/chin.199151325

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(2 citation statements)

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“…It is commonly found in jinna bark, tobacco leaves, carrot leaves, apples, peaches, coffee seeds, and a few in fungi and bacteria [ 23 ]. In addition to synthetic neuraminidase inhibitors GS401 and GS4104 [ 64 ], QA is widely used for the synthesis of anti-neoplastic agents (esperamicin-A), immunosuppressants (FK-506), anti-hepatits B drugs (BE-5), and chlorogenic acid, which are used for the prevention of cardiovascular disease, cancer, and the side effects of chemotherapy [ 65 , 66 ]. Furthermore, QA can be used as a food additive, a cosolvent, and an optical material.…”

Section: Sa Production By Metabolic Engineeringmentioning

confidence: 99%

“…It is rich in coffee, fruits, and vegetables and is the main source of caffeic acid in the human diet. Furthermore, chlorogenic acid prevents cardiovascular disease, cancer, and the side effects of chemotherapy; thus, it is one of the current research hotspots [ 65 ]. In E. coli , most of the DHQ is converted into DHS, and the remainder is converted into QA.…”

Section: Sa Production By Metabolic Engineeringmentioning

confidence: 99%

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Metabolic Engineering of Shikimic Acid Biosynthesis Pathway for the Production of Shikimic Acid and Its Branched Products in Microorganisms: Advances and Prospects

Chen

Lu³

et al. 2022

Molecules

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The shikimate pathway is a necessary pathway for the synthesis of aromatic compounds. The intermediate products of the shikimate pathway and its branching pathway have promising properties in many fields, especially in the pharmaceutical industry. Many important compounds, such as shikimic acid, quinic acid, chlorogenic acid, gallic acid, pyrogallol, catechol and so on, can be synthesized by the shikimate pathway. Among them, shikimic acid is the key raw material for the synthesis of GS4104 (Tamiflu®), an inhibitor of neuraminidase against avian influenza virus. Quininic acid is an important intermediate for synthesis of a variety of raw chemical materials and drugs. Gallic acid and catechol receive widespread attention as pharmaceutical intermediates. It is one of the hotspots to accumulate many kinds of target products by rationally modifying the shikimate pathway and its branches in recombinant strains by means of metabolic engineering. This review considers the effects of classical metabolic engineering methods, such as central carbon metabolism (CCM) pathway modification, key enzyme gene modification, blocking the downstream pathway on the shikimate pathway, as well as several expansion pathways and metabolic engineering strategies of the shikimate pathway, and expounds the synthetic biology in recent years in the application of the shikimate pathway and the future development direction.

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Section: Sa Production By Metabolic Engineeringmentioning

confidence: 99%

Section: Sa Production By Metabolic Engineeringmentioning

confidence: 99%