ChemInform Abstract: Studies on 5‐(Indan‐1′‐yl)tetrazoles as Potential Non‐Steroidal Antiinflammatory Agents.

Abstract

198 ChemInform Abstract The indancarbonitriles (IV), prepared from the carboxylic acids (I) via dehydration of the amides (III), are treated with sodium azide (V) to form the indanyltetrazoles (VI). These and the amides (III) show antiinflammatory activities comparable to phenylbutazone. The methoxy substituents in (VIb) and (VIc) cause a red-shift of λmax and increase in εmax.

Total Synthesis and Analgesic Activity of 6-Fluoroindan-1-acetic Acid and its 3-Oxo Derivative

“…6-Fluoro-3-oxo-indan-1-acetic acid (5) and 6-fluoroindan-1-acetic acid (6) were weighed in 20 mg each and taken into separate graduated test tubes. The compounds were then dissolved in 2 mL of saline solution and a few drops of 0.1N NaOH in saline.…”

“…For example, 1H-indene-3-acetic acid-5-fluoro-2-methyl-1-[4-(methylsulfinyl)-phenyl]methylene (Sulindac) and indan-1,3-dione are well known anti-inflammatory agents [3]. Recently, significant anti-inflammatory activity among a series of substituted indan-1-carboxylic acids has been reported [4], a number of methoxyindan-1-alkanoic acids have been synthesised with considerable anti-inflammatory properties [5], and indan derivatives with a halo-substituted indanyl group have been found to possess analgesic and anti-inflammatory properties [6][7][8][9]. It has been established that aromatic halogen substitution could increase the analgesic and antiinflammatory potency and widen the margin of safety [9].…”