ChemInform Abstract: Studies on the Reactivity of Some N‐Aryl‐ and N‐Heteroaryl‐N′‐alkylthioureas Towards Electrophilic Reagents. Synthesis of New N‐Pyridylthioureas and Thiazolines.

Abstract

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Thiourea and Guanidine Compounds and their Iridium Complexes in Drug-Resistant Cancer Cell Lines: Structure-Activity Relationships and Direct Luminescent Imaging

“…Monosubstitution of 1,1'-thiocarbonyldiimidazole was achieved by reaction with substoichiometric 2-aminobenzimidazole in acetonitrile. The second imidzoyl unit was displaced by a selection of amines (n-propylamine, n-butylamine, 32 n-hexylamine, and benzylamine) in the presence of dimethylaminopyridine (DMAP) in dimethylformamide (DMF) to give compounds 1S to 4S in 63 -81 % yield after purification. 22 Portions of these compounds were converted to the corresponding guanidines by reaction with mercury(II) oxide and methanolic ammonia in chloroform to give 1N to 4N 33,34 in 40 -65% yield.…”