ChemInform Abstract: Substituted 4,5‐Diaminopyrazoles in the Reaction with Chalcones and Acetylarenes.

Abstract

Substituted 4,5-Diaminopyrazoles in the Reaction with Chalcones and Acetylarenes.-The diaminopyrazole (I) reacts with the chalcones (II) or the acetophenones (IV) to give the pyrazolodiazepines (III) and (V) respectively. -(ORLOV, V. D.; KOLOS, N. N.; KIROGA, KH.; KALUSKI, Z.; FIGAS, E.; POTEKHIN, K. A.; Khim. Geterotsikl. Soedin. (1992) 4, 506-510; Khar'k. gos. univ. im. Gor'kogo, Khar'kov 310077, Ukraine; RU)

1,3,5-Tris-(2,3-dihydro-1H-1,5-benzodiazepin-4-yl)-1,2,3,4,5,6-hexahydro-s-triazine

“…A method for the preparation of 1,5-benzodiazepine derivatives corresponds to the condensation reaction between aromatic o-diamines with 1,3-dielectrophilic compounds such as acrylic acid, acrylic esters and acrylamides. This approach is quite versatile, which makes it appropriate for synthetic purposes [1][2][3][4][5][6]. Benzodiazepine moieties are well-known due to their wide range of pharmacological activities [7,8].…”