ChemInform Abstract: Substituted N,N‐Dimethyl‐3‐(phenylthio)‐ and ‐4‐(phenylthio) benzylamines.

Abstract

Substituted N,N-Dimethyl-3-(phenylthio)-and -4-(phenylthio) benzylamines.-Twelve selected derivatives of 3-phenylthio-and 4phenylthiobenzylamine are synthesized in order to determine the influence of the structural manipulation (positional isomerism) on the biological activity. The most interesting compound (IXa) shows affinity to cholinergic and 5-HT2 serotonin receptors in the rat brain and some properties considered to be indicative of antidepressant activity. -(SINDELAR, K.; KMONICEK, V.; HRUBANTOVA, M.; POLIVKA, Z.; Collect. Czech. Chem. Commun. 57 (1992) 1, 194-203; Res. Inst. Pharm. Biochem., 130 60 Prague 3, CSFR; EN)

Social Media in Emergencies: An examination of government accountability for risk communication and warning

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