ChemInform Abstract: SYNTHESIS AND ANTI‐INFLAMMATORY ACTIVITY OF SOME 2,3‐DIHYDRO‐1,4‐BENZOXAZEPIN‐5(4H)‐ONE‐7‐ACETIC ACID ESTERS

Abstract

Die Ester (I) werden mit Acrylonitril zu den Nitrilen (II) addiert.

Schmidt Reaction of E‐3‐Benzylidenechromanones and E‐3‐Benzylidenethiochromanones

“…Moreover, there are important variants of this reaction, developed mainly by Aubé et al [2,3], which include rearrangements through interactions of carbocations and alkyl azides or carbonyl compounds and alkyl azides, either intermolecularly or intramolecularly. Schmidt reaction of chromanones and their analogues has been studied by a number of groups [4][5][6][7][8][9][10][11][12][13]. Schmidt reaction of E-3-benzylideneflavanones (1) (Figure 1), done by us, produced some novel results [14][15][16].…”

Synthesis and structure–antibacterial activity relationship studies of 4-substituted phenyl-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-thiones

“…Among these activities, it is worth mentioning antithrombotic (Mishra et al, 2010), antiepileptic (Pekcec et al, 2009), anticonvulsant (Sharma et al, 2008), antiinflammatory (Schridhar et al, 1979;Verma et al, 2008), progesterone agonist (Dols et al, 2008), antifungal (Serrano-Wu et al, 2002), antagonist and analgesic (Okada et al, 1994;Hallinan et al, 1994), antipsychotic (Liegeois et al, 1994), anxiolytics (Effland et al, 1982), antihistaminic (Sleevi et al, 1991), antiaggregating (Aono et al, 1991), and epidermal growth factor receptor(EGFR) tyrosine kinase inhibitory (Smith et al, 2006) activities. Considering the structural characteristics of the benzoxazepine-3-ones, the existence of seven-membered heterocyclic ring system, fused aromatic group and the group -N-C(=O)-, similar to protein amide bond, it is reasonable to expect inherent physiological activities.…”