ChemInform Abstract: Synthesis and anti‐Parasitic Activity of a Novel Quinolinone—Chalcone Series.

Abstract

and pyrazole analogues such as (V) are designed, synthesized and evaluated for their antiparasitic activity. Compound (IIIe) exhibits anti-parasitic properties against the mammalian stages of Trypanosoma brucei and Leishmania infantum. Compounds (IIIa) and (IIIf) show potency toward the intracellular, amastigote stage of L. infantum. Promising trypanocidal compounds are also found for compounds (IIIb), (IIIe) as well as (IIIc) and (IIId). -(ROUSSAKI, M.; HALL, B.; COSTA LIMA, S.; CORDEIRO DA SILVA, A.; WILKINSON, S.; DETSI*, A.; Bioorg. Med. Chem. Lett. 23 (2013) 23, 6436-6441, http://dx.