ChemInform Abstract: Synthesis and Antiinflammatory Activity of Some New 6‐Methoxy‐α‐methyl‐2‐naphthalene Acetic Acid Derivatives.

Abstract

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Synthesis and biological evaluation of some novel benzoxazin-4-one and quinazolin-4-one derivatives based on anti-inflammatory commercial drugs

“…Additionally, several derivatives exhibited enhanced selectivity in COX-2 inhibition when compared to felbinac [8]. Many similar studies have also indicated that the inclusion of a heterocyclic moiety containing nitrogen atoms may ameliorate gastric tolerability while broadening the anti-inflammatory spectrum of compounds [9,10].…”

Combinatorial approach: identification of potential antifungals from triazole minilibraries

“…Solution phase techniques are, however, limited to short reaction sequences that either use reagents in stoichiometric quantities, or use reagents that can be easily separated from the final products (Patrick, 2003;Terret, 1998). Various derivatives of 1,2,4-triazole are known to exhibit pharmacological properties like antibacterial, antifungal anticancer, anti-viral, anti-inflammatory, CNS depressant and anticonvulsant activity (Amir and Azam, 2004;Amir et al, 1999;Banachiewicz et al, 2004, ColanceskaRagenovic et al, 2001, Metwally et al, 2007, Mishra et al, 1991Parmar et al, 1972;Ravi and Rajkannan, 2004). In this work, focus is mainly on combinatorial synthesis and high throughput screening of 1,2,4-triazole derivatives (shown in Scheme 1 and Table 1) and identification of hits for antifungal activity by 2D deconvolution analysis.…”