ChemInform Abstract: Synthesis and Antiinflammatory Activity of Some 3‐(2‐Thiazolyl)‐1,2‐benzisothiazoles.

Abstract

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Synthesis and Antimicrobial Studies of Some Novel Bis-[1,3,4]thiadiazole and Bis-thiazole Pendant to Thieno[2,3-b]thiophene Moiety

“…Furthermore, 1,3,4-thiadiazoles were recently reported as highly anti-inflammatory [ 10 , 11 ], and anticonvulsant agents [ 10 , 12 ]. Also, thiazoles and their derivatives found application in drug development for the treatment of allergies [ 13 ], hypertension [ 14 ], inflammation [ 15 ], schizophrenia [ 16 ], bacterial [ 17 ] and HIV infections [ 18 ]. Encouraged by all these findings and in continuation of our ongoing research program investigating the utilization of compound 1 as versatile and useful building blocks for the synthesis of a wide variety of bis-heterocycles systems [ 19 , 20 ], we report in the present work an efficient and rapid method for the synthesis of a series of thienothiophene pendant to thiadiazole or thiazole moieties.…”

Newer Substituted β-Aminonaphthalenes as Potent Anti-inflammatory Agents

“…Compounds having a furfyl group as substitutent (4, 9, 14) revealed the least % inhibition of oedema in rat paw, while compounds having phenyl ring with methoxy group either at ortho or para-position (as substituent) exhibited the maximum activity. Furthermore, compounds having a phenyl group as substituent (3,8,13) and Hence, it can be concluded that 1. Azetidinones possess more potent activity than their corresponding arylidenes.…”

A facile synthesis and anticancer activity of some novel thiazoles carrying 1,3,4-thiadiazole moiety

“…Also, it was reported that liver cancer is one from the top ten human cancers worldwide and among the top five of cancers in terms of mortality [ 2 , 3 ]. A literature survey revealed that thiazole derivatives had many biological activities as antihypertension [ 4 ], antifungal [ 5 ], antimicrobial [ 6 , 7 ], anti-inflammatory [ 8 ], antioxidant [ 9 ], antitubercular [ 10 ], and anticancer [ 11 – 14 ]. Moreover, 1,3,4-thiadiazole derivatives had many biological activities such as antibacterial, antifungal, antituberculosis, anti-hepatitis B viral, antileishmanial, anti-inflammatory, analgesic, CNS depressant, antioxidant, antidiabetic, molluscicidal, antihypertensive, diuretic, analgesic, antimicrobial, antitubercular, anticonvulsant and anticancer [ 15 – 24 ].…”