ChemInform Abstract: Synthesis and Antimicrobial Activity of Certain Benzimidazole and Fused Benzimidazole Derivatives.

Eisa, Hassan M.; Barghash, A.; Badr, Sahar; Farahat, Abdelbasset A.

doi:10.1002/chin.201109129

Cited by 11 publications

(10 citation statements)

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“…Furthermore, the benzimidazole ring is a structural bioisostere of some of the nucleobases existing in natural nucleotides, which can interact easily with the biopolymers in living systems [ 9 ]; this feature is often accepted as the responsible for its biological importance, either alone or as incorporated into different templates. It has been reported to show many pharmacological activities including antimicrobial, MAO or cyclooxygenase (COX) inhibitory, or anticholinesterase [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Besides, albendazole, mebendazole and tiabendazole are some examples of antimicrobial agents that carry the benzimidazole ring ( Figure 2 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors

et al. 2017

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The aim of this study was to investigate acetylcholinesterase (AChE), monoamine oxidase A (MAO-A), monoamine oxidase B (MAO-B), cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzyme inhibitory, and antimicrobial activities of a new series of 2-(4-substituted phenyl)-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole derivatives, for their possible use as multi-action therapeutic agents. Target compounds (n = 15) were synthesized under microwave irradiation conditions in two steps, and their structures were elucidated by FT-IR, 1H-NMR, 13C-NMR and high resolution mass spectroscopic analyses. Pharmacological screening studies revealed that two of the compounds (2b and 2j) have inhibitory potential on both COX-1 and COX-2 enzymes. In addition, cytotoxic and genotoxic properties of the compounds 2b, 2j and 2m were investigated via the well-known MTT and Ames tests, which revealed that the mentioned compounds are non-cytotoxic and non-genotoxic. As a concise conclusion, two novel compounds were characterized as potential candidates for treatment of frequently encountered inflammatory diseases.

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Section: Introductionmentioning

confidence: 99%

Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors

et al. 2017

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“…This establishes the effect of electronic effect of the 2-methoxy group on the antimicrobial activity of the Schiff base ligands. In the same vein, the study conducted by Eisa etal [23] indicated that the incorporation of 1,3,4-oxadiazole or 1,2,4-triazole at the 2-position enhanced the antimicrobial activity of the benzimidazole-based compounds. On chelation, however, the presence of the Cu(II) ion did not have a regular effect on the antimicrobial activity of the free ligands.…”

Section: Disc Diffusion Testmentioning

confidence: 89%

Copper(II) complexes of substituted salicylaldimines with benzimidazole nucleus: synthesis, characterization and antimicrobial activity

Sobola

Watkins

2017

JRRS

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The aim of this study was to synthesize and evaluate the antimicrobial activity of Cu(II) complexes of some substituted salicylaldimines with benzimidazole nucleus. The salicylaldimine ligands were prepared by condensing 2-aminobenzimidazole with salicylaldehyde, o-vanillin and p-vanillin. All the compounds and the Cu(II) complexes were characterized by elemental , electronic, infrared and molar conductivity data. In addition, the structures of the ligands were confirmed with 1H-NMR and 13C-NMR spectral data. Both the ligands and the Cu(II) complexes have been screened for their in vitro antimicrobial activity against Staphylococcus aureus subsp. aureus ATCC® 6538™, Bacillus substillis subsp. spizizenii ATCC® 6633™*, Escherichia coli ATCC® 8739™* and Candida albicans ATCC® 2091™* using agar diffusion and broth dilution techniques. The ligands coordinated to the Cu(II) ion in a 1:2 (M:L) ratio as tridentate monobasic species via the imine-N, the imidazole-N and the phenolic–O to give six-coordinated Cu(II) complexes. The free ligands exhibited varying antimicrobial activity on the tested organisms from low activity to significant potency. Candida albicans was specifically susceptible to the o-vanillin Schiff base ligand. The presence of Cu(II) ion, however, did not have a regular effect on the activity of the compounds.

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“…Model building: The current study was performed using the following programs: VLife MDS 4.0 which GA batch docking. The structures of substituted benzimidazole were drowning in Vlife Engine >>tools>>draw 2D molecule and molecule was saved in Dot Mol format [26].…”

Section: Experimental Methodsmentioning

confidence: 99%

Docking Studies of Benzimidazole Derivatives as Coenzyme-A Carboxylase (ACCase) Inhibitor

More¹

2012

J AIDS Clinic Res 2012

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ChemInform Abstract: Synthesis and Antimicrobial Activity of Certain Benzimidazole and Fused Benzimidazole Derivatives.

Cited by 11 publications

References 0 publications

Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors

Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors

Copper(II) complexes of substituted salicylaldimines with benzimidazole nucleus: synthesis, characterization and antimicrobial activity

Docking Studies of Benzimidazole Derivatives as Coenzyme-A Carboxylase (ACCase) Inhibitor

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