ChemInform Abstract: Synthesis and Antimicrobial Activity of (Z)‐4‐(4‐Substituted‐thiazol‐2‐yl)‐1‐(2‐oxoindolin‐3‐ylidene) Semicarbazide and Its Derivatives.

Basavarajaiah, S. M.; Mruthyunjayaswamy, B. H. M.

doi:10.1002/chin.201051125

Cited by 4 publications

(4 citation statements)

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“…All the chemicals are of analytical reagent grade and the solvents were purified according to standard methods [9]. The precursor 4-phenylthiazole-2-semicarbazide is synthesized by reported method [10,11]. The metal (II) hydrates are used as such procured.…”

Section: Methodsmentioning

confidence: 99%

“…The medium intensity sharp band observed at 1600 cm -1 is assigned to C=N group. An intense band at 691cm -1 is due to the characteristic vibrations of the C-S-C thiazole ring while the high intensity band observed at 1257 cm -1 is assigned to the phenolic C-O vibration [11,13]. The disappearance of weak band in the ligand (HL), which was appeared at 2895 cm -1 indicated the deprotonation of intramolecular hydrogen bonded phenolic -OH group upon complexation with metal ions.…”

Section: Ft-ir Spectral Studiesmentioning

confidence: 99%

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Synthesis, Characterization, Fluorescence and Antimicrobial studies of Cu(II), Co(II), Ni(II), Zn(II) and Cd(II) complexes derived from Schiff’s base (E)-2-(5-chloro-2-hydroxybenzylidene)-N-(4-phenylthiazol-2-yl)hydrazinecarboxamide

Rahaman¹,

Gupta²,

Gautam³

et al. 2021

JUSST

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A series of Cu(II), Co(II), Ni(II), Zn(II) and Cd(II) complexes of (E)-2-(5-chloro-2-hydroxybenzylidene)-N-(4-phenylthiazol-2-yl)hydrazinecarboxamide (HL) with ONO donor ligand was synthesized. The ligand (HL) was prepared by the condensation of N-(4-phenylthiazol-2-yl)hydrazinecarboxamide with 5-chloro-2-hydroxybenzaldehyde. The HL and its metal complexes have been characterized using elemental analysis and various spectral techniques such as, FTIR, 1H and 13C NMR, Mass, UV–Visible, ESR, thermal analysis (TGA), magnetic moment, conductivity and powder-XRD. The Powder XRD pattern indicates hexagonal or tetragonal system for HL and its metal complexes. The fluorescence studies exhibits strong emission in the range of 400-500 nm for HL. Further in comparison the HL, Zn(II) and Cd(II) complexes showed enhanced emission whereas Cu(II), Co(II) and Ni(II) showed poor emission. The antimicrobial activities of the HL and its metal complexes were studied by minimum inhibitory concentration (MIC) method wherein the metal complexes showed better activity as compare to free ligand.

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Section: Methodsmentioning

confidence: 99%

Section: Ft-ir Spectral Studiesmentioning

confidence: 99%

Synthesis, Characterization, Fluorescence and Antimicrobial studies of Cu(II), Co(II), Ni(II), Zn(II) and Cd(II) complexes derived from Schiff’s base (E)-2-(5-chloro-2-hydroxybenzylidene)-N-(4-phenylthiazol-2-yl)hydrazinecarboxamide

Rahaman¹,

Gupta²,

Gautam³

et al. 2021

JUSST

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“…The nine conformations of each compound, along with the Vina score and RMSD value, were used to screen for the best binding interaction. The interaction of the ligands was analyzed using the 2D interaction diagrams generated by using LigPlot + and 3D interaction images using PyMOL [35,36].…”

Section: Molecular Docking Studiesmentioning

confidence: 99%

Design, Synthesis, Spectral analysis, Drug likeness prediction, and molecular docking investigations of new naphtho[2,1-b]furan encompassing pyrimidines as potential antimicrobial agents

L¹,

Mathada²,

2023

Preprint

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In view of the extremely important biological and medicinal properties of napthofurans, the synthesis of these heterocycles has fascinated the interest of medicinal and organic chemists. Keeping this in mind, we herein reporting synthesis, and antimicrobial evaluation of 4-N-aryl -naphtho[2,1-b]furo[3,2-d] pyrimidines 5 (a-l). Structures of these synthesized compounds were confirmed by spectral analysis like IR, NMR and Mass spectrometry. The In vitro antimicrobial activities were reported for the all compounds 5 (a-l). The compounds 5e and 5f exhibited excellent antibacterial, antifungal and antidermatophytic activities against tested pathogens at MIC 3.125, and 3.125g/ml respectively. Furthermore, molecular docking studies of these compounds against Staphylococcus aureus tyrosyl-tRNA synthetase (PDB ID: 1JIJ), S. Aureus Gyrase (PDB ID: 2XCT) and SARS-CoV-2 Omicron (PDB ID: 7TOB), revealed the potential binding mode of the ligands to the site of the appropriate targets. Finally, drug likeness and structures activity relationship studies also disclosed.

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“…Similarly, the unsubstituted benzene moiety of 2-(unsubstituted)thiazole-4-carboxaldehyde 4h displayed significant inhibition, while the presence of an electron-withdrawing group led to a reduction in inhibition activity [41]. Moreover, the methyl-thiosemicarbazidecontaining thiazole ring in compound 4i exhibited noteworthy inhibition, probably due to the methyl substituent increasing the lipophilicity of the thiosemicarbazide moiety, thereby enhancing antibacterial efficacy [42,43]. Conversely, the methylthiosemicarbazide containing a 3-methylacetoin ring in 4k demonstrated effective inhibition, as the methylacetoin group's hydrophilic (hydroxyl group) and lipophilic (two methyl groups) nature, coupled with the methyl-thiosemicarbazide moiety, contributed to enhanced antibacterial efficacy [44].…”

Section: Structure-activity Relationship (Sar)mentioning

confidence: 99%

Microwave‐assisted solvent‐free synthesis of some novel thiazole‐substituted thiosemicarbazone analogues: antimicrobial and anticancer studies

Hossan

2023

Luminescence

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The increased resistance to antibiotics has compelled researchers to devise novel active compounds targeting multidrug‐resistant pathogenic microorganisms. A series of thiosemicarbazone derivatives were synthesized by reacting thiosemicarbazide with 2‐aryl‐4‐formylthiazole, 2‐aryl‐5‐formyl‐4‐methylthiazole, and/or 5‐acetyl‐2‐aryl‐4‐methylthiazole compounds. These thiosemicarbazone‐based thiazole adducts were evaluated for their inhibitory activities against tuberculosis H37Ra and Bovis BCG mycobacteria. Their cytotoxicity was assessed against two cancer cell lines: colonic carcinoma (HCT‐116) and cervical cancer (HeLa). Notably, these thiosemicarbazones exhibited minimal cytotoxic effects on these cell lines even at their highest concentrations. Furthermore, the prepared thiosemicarbazone derivatives demonstrated significant antimicrobial efficacy against Bacillus subtilis and Staphylococcus aureus (gram‐positive bacterial pathogens) as well as Escherichia coli and Pseudomonas fluorescens (gram‐negative bacterial pathogens). While most of the prepared thiosemicarbazone derivatives exhibited moderate activity against Candida albicans (a fungal strain), their performance was notable. The thiosemicarbazone‐based thiazole adducts were also successfully synthesized using a solvent‐free approach under microwave irradiation. Compared with conventional reflux methods, the microwave‐assisted technique yielded high thiazole yields within just 5 minutes, obviating the need for catalysis. This study signifies significant strides toward the rational design of more potent antimycobacterial agents.

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ChemInform Abstract: Synthesis and Antimicrobial Activity of (Z)‐4‐(4‐Substituted‐thiazol‐2‐yl)‐1‐(2‐oxoindolin‐3‐ylidene) Semicarbazide and Its Derivatives.

Cited by 4 publications

References 0 publications

Synthesis, Characterization, Fluorescence and Antimicrobial studies of Cu(II), Co(II), Ni(II), Zn(II) and Cd(II) complexes derived from Schiff’s base (E)-2-(5-chloro-2-hydroxybenzylidene)-N-(4-phenylthiazol-2-yl)hydrazinecarboxamide

Synthesis, Characterization, Fluorescence and Antimicrobial studies of Cu(II), Co(II), Ni(II), Zn(II) and Cd(II) complexes derived from Schiff’s base (E)-2-(5-chloro-2-hydroxybenzylidene)-N-(4-phenylthiazol-2-yl)hydrazinecarboxamide

Design, Synthesis, Spectral analysis, Drug likeness prediction, and molecular docking investigations of new naphtho[2,1-b]furan encompassing pyrimidines as potential antimicrobial agents

Microwave‐assisted solvent‐free synthesis of some novel thiazole‐substituted thiosemicarbazone analogues: antimicrobial and anticancer studies

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