ChemInform Abstract: Synthesis and Antioxidant Activity Evaluation of New Hexahydropyrimido[5,4‐c]quinoline‐2,5‐diones and 2‐Thioxohexahydropyrimido[5,4‐c]quinoline‐5‐ones Obtained by Biginelli Reaction in Two Steps.

Abstract

Steps. -(ISMAILI, L.; NADARADJANE, A.; NICOD, L.; GUYON, C.; XICLUNA, A.; ROBERT, J.-F.; REFOUVELET*, B.; Eur.

Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists

“…The synthesis procedure for racemic compounds 9aeb, using Biginelli's multicomponent method [21] (Scheme 2) was the same as that for 9ceh (see Table 3). …”

“…Following our studies on the synthesis of quinolines carried out in our laboratory [21], we now report the synthesis of new 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamides and new 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbohydrazides.…”

“…These new compounds and some of our previously designed hexahydropyrimido [5,4-c]quinoline-2,5-diones [21] were tested as AChE and BuChE inhibitors.…”

Starch Sulfuric Acid: an Alternative, Eco-Friendly Catalyst for Biginelli Reaction

“…To circumvent this problem, a variety of new catalysts has been introduced in the literature. In recent years, many protocols involving the use of Lewis and Bronsted acids such as graphite supported lanthanum chloride, [5] alumina supported MoO 3 [6], antimony(III) chloride [7], copper(II) tetrafl uoroborate [8], bismuth nitrate [9], iron(III) trifl uoroacetate and trifl uoromethanesulfonate [10], yttrium(III) nitrate hexahydrate [11], TaBr 5 [12], Trichloroisocynuric acid (TCCA) [13], PSSA [14], chloroacetic acid [15], p-TsOH [16], HCl [17], acetic acid [18], silica sulfuric acid [19], concentrated H 2 SO 4 [20], H 3 BO 3 [21], HBF 4 [22], chiral phosphoric acid [23], H 3 PW 12 O 40 [24], H 3 PMo 12 O 40 [25], Al 2 O 3 /MeSO 3 H [26], HClO 4 doped silica [27], bentonite/PS-SO 3 H nanocomposite [28], sulfated tungstate [29], imidazol-1-yl-acetic acid [30], zeolite-supported HPA [31] and a number of other catalysts [32][33][34][35][36][37][38] are reported. However, at a practical level, these often require relatively harsh reaction conditions such as high reaction temperatures, expensive or highly acidic catalysts, and prolonged reaction times.…”

One-Pot synthesis of dihydropyrimidinones by dodecylphosphonic acid as solid Bronsted Acid Catalyst under Solvent-Free Conditions via Biginelli condensation

“…In recent years, many protocols involving the use of Lewis and Bronsted acids such as graphite supported lanthanum chloride, [5] alumina supported MoO 3 [6], antimony(III) chloride [7], copper(II) tetrafluoroborate [8], bismuth nitrate [9], iron(III) trifluoroacetate and trifluoromethanesulfonate [10], yttrium(III) nitrate hexahydrate [11], TaBr 5 [12], TCCA [13], PSSA [14], chloroacetic acid [15], p-TsOH [16], HCl [17], acetic acid [18], silica sulfuric acid [19], concentrated H 2 SO 4 *Corresponding author. E-mail: sardarian@ susc.ac.ir [20], H 3 BO 3 [21], HBF 4 [22], chiral phosphoric acid [23], H 3 PW 12 O 40 [24], H 3 PMo 12 O 40 [25], and Al 2 O 3 /MeSO 3 H [26] are reported.…”