ChemInform Abstract: SYNTHESIS AND ANTIVIRAL ACTIVITY OF SUBSTITUTED 5‐UREIDO‐ AND 5‐THIOUREIDOBENZIMIDAZOLE DERIVATIVES

Willitzer, Horst; Braeuniger, H.; Engelmann, D.; Krebs, D.; Ozegowski, Werner; Tonew, M

doi:10.1002/chin.197828171

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“…Compounds 1 and 2 were prepared from 1-bromo-2,4-dinitrobenzene by reaction with ethyl/cyclopentylamine in DMF according to the literature 22 . The 2-nitro group of compounds 1 and 2 was reduced to 2-amino (3 and 4) by using Na 2 S/NaHCO 3 in methanol 22 . Condensation of o-phenylenediamines (3 and 4) with the Na 2 S 2 0 5 adduct of appropriate benzaldehydes in DMF 23 gave 5-7.…”

Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1‐Bromo‐2,4‐dinitrobenzene and Their Antifungal Activities

Ahmadi

Nahri-Niknafs

2011

Journal of Chemistry

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Six novel benzimidazole derivatives, 5-nitro-2-phenyl -1-ethyl benzimidazol (5), 2- (p-bromophenyl)- 5-nitro- 1-ethyl benzimidazol (6), 2- (p-bromophenyl-5-nitro-1–cyclopentyl benzimidazol (7), 2- (p-bromophenyl) -5-nitro-1-cyclopentyl benzimidazol (8), 5-amino-2-(p-bromophenyl)-1-ethylbenzimidazol (9) and 5-amino-2-(p-bromophenyl)-1-cyclopentyl benzimidazol (10) were synthesized. The structures of all the synthesized compounds were elucidated by using elemental analysis and different spectroscopic techniques (IR, NMR and mass spectroscopy). Some of these compounds showed potential antifungal activities. The biological activity of these compounds as fungicides was tested against Candida albicans, patient isolate Candida glabrata and Candida krusei. The biological activity of four compounds was found to be comparable to that of the commercially available fungicides with a minimum inhibitory concentration of 12.5 µg/mL.

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Section: Resultsmentioning

confidence: 99%

Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1‐Bromo‐2,4‐dinitrobenzene and Their Antifungal Activities

Ahmadi

Nahri-Niknafs

2011

Journal of Chemistry

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ChemInform Abstract: SYNTHESIS AND ANTIVIRAL ACTIVITY OF SUBSTITUTED 5‐UREIDO‐ AND 5‐THIOUREIDOBENZIMIDAZOLE DERIVATIVES

Abstract: Aus dem Dinitrochlorbenzol (I) werden über die Dinitraniline (III) die Nitro‐ und Aminobenzimidazole (VII) und (VIII) hergestellt und mit Isocyanaten, Isothiocyanaten und Aldehyden umgesetzt.

Cited by 1 publication

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Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1‐Bromo‐2,4‐dinitrobenzene and Their Antifungal Activities

Synthesis, Characterization of Some Novel Benzimidazole Derivatives of 1‐Bromo‐2,4‐dinitrobenzene and Their Antifungal Activities

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