ChemInform Abstract: Synthesis and Antiviral Activity of Hydrophosphorylated Inosine Derivatives.

Abstract

Synthesis and Antiviral Activity of Hydrophosphorylated InosineDerivatives.-Inosine dialdehyde (I) reacts with the amines or amino acids (II) and hypophosphorous acid to give the hydrophosphorylated hypoxanthylmorpholines (IV), which are low-toxic compounds with activity against RNA and DNA containing viruses. -(BELAKHOV, V. V.; LEVINA, A. A.; SHENIN, YU. D.; INONIN, B. I.; SHTIL'BANS, E. B.; RACHKOVSKAYA, L. A.; CHEKUNOVA, E. V.; MARENNIKOVA, S. S.; SHNEIDER, M. A.; Khim. -Farm. Zh. 24 (1990) 9, 44-48; VNI tekhnol. inst. antibiot. i ferment. med. naznacheniya, Leningrad, USSR; RU)