ChemInform Abstract: Synthesis and Antiviral Evaluation of Novel 5‐(N‐Arylaminomethyl‐1,3,4‐oxadiazol‐2‐yl)hydrazines and Their Sugars, 12,4‐Triazoles, Tetrazoles and Pyrazolyl Derivatives.

Abdel‐Aal, Mohammed T.; El-Sayed, Waled A.; El-Kosy, Salah M; El-Ashry, E. S. H.

doi:10.1002/chin.200835127

Cited by 6 publications

(2 citation statements)

References 1 publication

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“…Recent works have highlighted that the sulfone group, which has an ideal structure for developing agrochemicals and is found in many biologically active compounds, also exhibits various biological activities including antibacterial, 6−15 antifungal, 16−20 antiviral, 21,22 insecticidal, 23 and herbicidal 24 activities. Meanwhile, 1,3,4-oxadiazole ring, a common feature of medicinal agents, exhibits various biological activities, such as antibacterial, [6][7][8][9][10][11][12][13][14][15]25 antifungal, 16−21 antiviral, 21,22,26,27 insecticidal, 28−31 herbicidal, 32,33 and nematocidal 25 activities. In our previous work, we investigated the biological properties of some series of sulfone derivatives containing a 1,3,4-oxadiazole moiety, which, compared with commercial bactericides, showed better antibacterial activities against Ralstonia solanacearum (R. solanacearum), Xoo, Xac, and Xanthomonas oryzae pv.…”

Section: ■ Introductionmentioning

confidence: 99%

Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active Antibacterial Agents

Xie

et al. 2018

J. Agric. Food Chem.

138

144

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This study aimed to synthesize some new sulfone derivatives containing a 1,3,4-oxadiazole moiety and investigate their in vitro antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac), the pathogens of rice bacterial leaf blight and citrus canker, respectively, by performing turbidimeter tests. Antibacterial bioassay results showed that compound 6d revealed excellent bioactivities against Xoo and Xac, with the 50% effective concentration (EC50) values of 0.17 and 1.98 μg/mL, respectively, compared with thiodiazole copper (121.82 and 77.04 μg/mL, respectively) and bismerthiazol (92.61 and 58.21 μg/mL, respectively). Meanwhile, greenhouse-condition trials indicated that, compared with thiodiazole copper and bismerthiazol, compound 6d more effectively reduced rice bacterial leaf blight.

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Section: ■ Introductionmentioning

confidence: 99%

Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active Antibacterial Agents

Xie

et al. 2018

J. Agric. Food Chem.

138

144

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“…1,2,4-Triazole derivatives are known to exhibit a wide range of biological activities, such as antibacterial [1][2][3][4] and antifungal [1][2][3][4][5], analgesic [6], anticancer [7,8], antiviral [9], antitubercular [10,11], anti-in�ammatory [12], anticonvulsant [13,14], antidepressant [15], and central nervous system (CNS) [16]. A number of 1,2,4-triazole-3-one and its heterocyclic derivatives represent an interesting class of compounds possessing a broad spectrum of biological activities like antimicrobial [17,18], anticonvulsant [19,20], and 5-HT2 antagonists [21].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of Some [1,2,4]‐Triazole Derivatives

Patil

Krishnamurthy

Shashikumar

et al. 2012

Journal of Chemistry

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A series of novel [1,2,4]-triazolo piperidine (8), [1,2,4]-triazolo piperazine (9a-c), [1,2,4]-triazolo phenylether (10a-e), and [1,2,4]-triazolo aniline (11a-c) derivatives have been synthesized. The chemical structures of the newly synthesized compounds were characterized by IR,1H NMR,13C NMR, and LCMS. The newly synthesized compounds were screened for antimicrobial activity. Among all the compounds tested,11b(R4=4-MeO–) showed the highest activity againstStaphylococcus aureusandEscherichia coli, and9a(R1andR2=Cl) showed the highest activity againstPseudomonas aeruginosa.

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New Insights into Chemistry and Anti-Infective Potential of Triazole Scaffold

Kharb

Yar²,

Sharma³

2011

CMC

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Research and development for novel substances possessing anti-infective activity have attracted considerable attention due to the escalating resistance towards conventional antibiotics. Therefore, the discovery and development of effective antimicrobial drugs with novel mechanism of action have become an insistent task for infectious diseases research programs. Triazole scaffold has been consistently rewarded as a promising versatile lead molecule with a pivotal position in modern medicinal chemistry. The literature reveals that this heterocyclic moiety has drawn attention of the chemists, pharmacologists, microbiologists and other researchers owing to its indomitable biological potential as anti-infective agents. The present communication is a cogent attempt to review the chemistry and antimicrobial activities of triazole derivatives reported in recent scientific literature. The biological profiles of these new triazole derivatives represent a fruitful matrix for further development as promising and superior anti-infective medicinal agents.

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ChemInform Abstract: Synthesis and Antiviral Evaluation of Novel 5‐(N‐Arylaminomethyl‐1,3,4‐oxadiazol‐2‐yl)hydrazines and Their Sugars, 12,4‐Triazoles, Tetrazoles and Pyrazolyl Derivatives.

Cited by 6 publications

References 1 publication

Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active Antibacterial Agents

Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active Antibacterial Agents

Synthesis and Antimicrobial Activity of Some [1,2,4]‐Triazole Derivatives

New Insights into Chemistry and Anti-Infective Potential of Triazole Scaffold

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