ChemInform Abstract: Synthesis and Biological Evaluation of Some New 2,5‐Disubstituted 1,3,4‐Oxadiazoles from 3‐(Arylsulfonyl)propanehydrazides.

Abstract

are prepared and screened for their antimicrobial activities. (IIIa) and (IIIb) are the most active compounds. -(KUMAR, L. V.; NAIK, P. J.; NAVEEN, M.; CHANDRASEKHAR, T.; REDDY, A. B.; PENCHALAIAH, N.; SWAMY*, G. N.; Indian J.

Synthesis and Antibacterial Studies of new mixed ligand transition metal complexes of thioester (1, 3, 4-Oxadiazole) derivative (phozbt) and dppe Ligands.

“…The carbon-NMR spectrum of (phozbt) was recorded in dimethyl sulfoxide solvent. The carbonyl carbon band displayed at (174.43) ppm; C 7 (Joshi et al, 2015).The two carbon atom (C 6 and C 5 ) of oxadiazole ring occurred at (164.55 and 157.64) ppm respectively (Kumar et al, 2014). The peaks observed at (133.62, 132.81, 130.53 and 128.09) ppm were correspondingly ascribed to aromatic benzo carbon of (C 8 , C 11 , C 10 and C 9 ) (Almajan et al, 2008).…”

“…The dissaperance of the SH band at (2.5) ppm that remarked in (phoztH) ligand indicates the formation of the thioester (phobt) ligand (figure 1) (Husain and Ajmal, 2009) (Kumar et al, 2014). 10' Figure 1: 1 H-NMR spectrum of (phozbt) ligand…”

Untitled

“…Kumar et al [87] synthesized some new 2,5-disubstitued 1,3,4-oxadiazoles from (3-arylsulfonyl) propane hydrazides Maddela et al [88] reported ten new N'-subtituted-2-methylquinoline-3-carbohydrazide (38) and screened for in vitro antimicrobial and antioxidant activities. The results clearly revealed that all ten compounds possess in vitro antioxidant activity at the tested dose as compared to the standard drug, ascorbic acid as shown in Figure 11.…”

Synthesis of Sulfonated Dihydrofuropyrazoles Derivatives as Antimicrobial Active Agents

“…These are widely used as antimicrobial agents, antidiabetic agents, diuretics, anticonvulsants, antiretroviral and Hepatitis-C antiviral agents. Several researches revealed that the broad spectrum antimicrobial activity of sulfone containing heterocycles entities [2][3][4][5][6][7][8][9][10] Recently, Kudruavtsev et al [11] reported that the sulfone bearing pyrrolidine derivatives inhibits Staphylococcus aureus sortase SrtA isoform, irreversibly by modification of enzyme cys 184.…”

“…: 145.2 °C, IR (KBr, νmax, cm -1 ): 3321, 3265, 3028, 3002, 2995, 1789, 1636, 1622, 1518, 1221, 1180, 1082, 960, 882, 766; 1 H NMR (400 MHz, CDCl3) δ 12.58 (br s, 1H), 7.40 (m, 10H), 5.29 (d,J = 4.2 Hz,1H),5.19 (d,J = 4.2 Hz,1H),4.21 (q,J = 7.6 Hz,2H),3.58 (t,J = 8.2 Hz,2H),3.11 (t,J = 8.2 Hz,2H),1.29 (t,J = 7.8 Hz,3H) ppm; 13 C NMR (100 MHz, CDCl3) δ 171. 5,163.7,143.4,140.2,136.4,129.3,128.9,128.6,127.7,125.9,125.1,113.4,87.6,61.6,41.7,35.6,29.6,14.2 ppm;HRMS (ESI,m/z): 417.1249 calcd. for C22H22N2O3S (M+Na) found: 417.1247.…”