ChemInform Abstract: Synthesis and Biological Study of Oxopyrimidines and Thiopyrimidines of 2‐(2,4‐Dichlorophenyl)imidazo[1,2‐a]pyridin‐3‐carbaldehyde.

Ladani, M. J.; Tala, S. D.; Akbari, J. D.; Dhaduk, M. F.; Joshi, H. S.

doi:10.1002/chin.200940149

Cited by 3 publications

(4 citation statements)

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“…Imidazo [1,2-a] pyridine are bridge head nitrogen heterocycles and compounds containing this heterocycles have been reported for various biological activities and received considerable interest from the pharmaceutical industry like antifungal and antimicrobial agents [3][4][5][6][7][8][9][10][11] . In order to prepare parent compound of 2-substituted imidazo (1,2-a) pyridine, a known procedure will be used by condensation of suitable 2-amino pyridine with different "-halo ketones in refluxing ethanol to give 2-substituted imidazo (1,2-a) pyridine and introduce it in different reactions 4 .…”

Section: Introductionmentioning

confidence: 99%

“…The chalcones have been discovered to be useful for the synthesis of variety of heterocyclic compounds such thiopyrimidines and oxopyrimidines. It is worth to mention oxypyrimidine and thiopyrimidines derivatives represent one of the most important class of compounds having a wide range of biological activities such as anti HIV, antiviral and herbicidal 10 . These active compounds have been synthesized by cyclocondensation of chalcones with urea and thiourea [2][3][4][5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

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Hepatoprotective Potentials of Promising Newly Synthesized 3-substituted-2-biphenyl Imidazo (1,2-a) Pyrimidine Derivatives on CCl4 Induced Albino Male Mice

A¹,

Mah²,

Owa³

2020

Asian J. of Biological Sciences

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Background and Objective: Synthesis of new compound with appropriate therapeutic importance is a major challenge in medicinal chemistry. Recently fused rings compounds of pyridine and pyrimidine have significant importance in the pharmaceutical industry due to their various interesting biological activities displayed over a broad range of therapeutic classes, therefore development of some novel fused heterocycles is the main goal of the present study. Materials and Methods: Thus, a simple and cost effective procedure, novel fused heterocycles compounds of 3-substituted heterocyclic compounds containing bridge head nitrogen were synthesized through multi step reactions to give new compound of 2-biphenyl-3-oxypyrimidine imidazo (1,2-a) pyrimidine. In addition, all prepared compounds were characterized via Fourier Transform Infrared (FT-IR) spectroscopy, some of them were characterized by Hydrogen-1-Nuclear MagneticResonance ( 1 H-NMR) spectroscopy. These new 3-substituted derivatives of imidazo/pyrimidine rings were tested in vivo by determining these activities on liver function enzymes Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT) and Alanine Aminotransferase (ALT) in addition to evaluating the hepatoprotective activity on liver tissue after treatments with these compounds alone or after interaction with the toxic compound carbon tetrachloride CCl 4 . Results: These compounds showed promising antitumor activity by reducing the level of liver function enzyme to or near the normal level when given alone or after interactions with CCl 4 for GOT, GPT and ALP, respectively. Also, all synthesized compounds had the ability to return liver tissue to normal state after damaged by CCl 4 .a] pyrimidine -3-yl]-4-nitro pyrimidine -2 (1H)-one expressed hepatoprotective activity against damaged caused by CCl 4 at enzyme level or liver tissue.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Potentials of Promising Newly Synthesized 3-substituted-2-biphenyl Imidazo (1,2-a) Pyrimidine Derivatives on CCl4 Induced Albino Male Mice

A¹,

Mah²,

Owa³

2020

Asian J. of Biological Sciences

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show abstract

“…The chalcones have been discovered to be useful for the synthesis of variety of heterocyclic compounds such thiopyrimidines and oxopyrimidines. It is worth to mention oxypyrimidine and thiopyrimidines derivatives represent one of the most important class of compounds having a wide range of biological activities such as anti HIV, antiviral and herbicidal, [11]. These active compounds have been synthesized by cyclocondesation of chlcones with urea and thiourea, [2,9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of some New 3-Substituted Heterocyclic Compounds Containing Bridgehead Nitrogen from 2-Amino Pyridine with Study Their Biological Activity

Al-Lami

Mahmoud

2018

ANJS

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New series of 3-substituted heterocyclic compounds containing bridge head nitrogen were synthesized through multi-step reactions. In order to prepare the starting 2-substituted heterocyclic compounds of pyridine, a known procedure was used by condensation of 2-amino pyridine with (4-bromo phenacyl bromide). Carbaldehyde group was introduced at position-3 of prepared 2-substituted imidazo / pyridine rings by Vilsmeier-Haack reaction. 3-Carbaldehyde derivatives underwent Claisen condensation with different aryl ketons to give unsaturated ketones of these derivatives, which on cyclization with urea and thiourea afforded 3-cyclic oxopyrimidines and thiopyrimidines derivatives of imidazo / pyridine rings. In addition, 3-carbaldehyde derivatives was reacted with hydrazine, semicarbazide and hydroxyl amine hydrochloride to yield new hydrazone, semicarbazone and oxime derivatives of imidazo / pyridine rings. All prepared compounds were characterised via FT-IR spectroscopy, some of them were characterised by 1 H-NMR spectroscopy. These new 3-subistituted derivatives of imidazo /pyridine rings were tested in different species bacterial and fungi. Some of tested compounds showed strong activity while the other showed moderate against. Interestingly, All these new prepared compounds showed high activity against fungi.

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“…It was our main objective to synthesize [10][11][12][13] the disperse dyes consisting thiazole with azo substituent which further utilized to dye some hydrophobic �bers, to characterize, to evaluate their fastness properties. e dyes were screened for their antimicrobial properties because a large number of natural products and drugs comprises of this heterocyclic moiety [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Disperse Dyes Based on Thiazole, Their Dyeing Application on Polyester Fiber and Their Antimicrobial Activity

Zadafiya¹,

Tailor²,

Malik³

2012

Journal of Chemistry

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Various diazotized aryl amines were coupled with N-(4-nitrophenyl)-2-[(4-phenyl-1,3-thiazol-2-yl)amino]acetamide to give the corresponding various azo disperse dyes (D1-D13). These dyes were applied to polyester fiber by HTHP method and their fastness properties were evaluated. Dyes were characterized by IR, elemental analysis, and NMR spectral studies. These dyes showed very good antibacterial and antifungal activities.

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ChemInform Abstract: Synthesis and Biological Study of Oxopyrimidines and Thiopyrimidines of 2‐(2,4‐Dichlorophenyl)imidazo[1,2‐a]pyridin‐3‐carbaldehyde.

Cited by 3 publications

References 1 publication

Hepatoprotective Potentials of Promising Newly Synthesized 3-substituted-2-biphenyl Imidazo (1,2-a) Pyrimidine Derivatives on CCl4 Induced Albino Male Mice

Hepatoprotective Potentials of Promising Newly Synthesized 3-substituted-2-biphenyl Imidazo (1,2-a) Pyrimidine Derivatives on CCl4 Induced Albino Male Mice

Synthesis of some New 3-Substituted Heterocyclic Compounds Containing Bridgehead Nitrogen from 2-Amino Pyridine with Study Their Biological Activity

Disperse Dyes Based on Thiazole, Their Dyeing Application on Polyester Fiber and Their Antimicrobial Activity

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