ChemInform Abstract: Synthesis and Biological Activity of Some 4‐Substituted Pyrimidines and Fused Pyrimidines.

Abstract

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Studies on the reaction of N‐(3‐carbethoxy‐4,5,6,7‐tetrahydrobenzo[b]thien‐2‐yl)‐N′‐phenylthiourea with hydrazine hydrate (Part 1)

“…205-207 °C in 50% yield as previously reported [16]. A tlc of the reaction products showed the presence of two compounds which could be separated by recrystallization and identified as the two isomeric products 2-hydrazino-3-phenyl-5,6,7,8tetrahydrobenzo [b]thieno [2,3-d]pyrimidin-4(3H)-one (3) and 3-amino-2-phenylamino-5,6,7,8-tetrahydrobenzo [b]thieno [2,3-d] pyrimidin-4(3H)-one (4).…”

“…The ultraviolet spectra were recorded using UV-2011 PC, UV-Vis scanning spectrophotometer-shimadzu. The infrared spectra were recorded on IR-470, IR spectrophotometer-shimadzu-using KBr and CCl 4 . The 1 H-NMR spectra were recorded by either varian EM-390 (90 MHz) or by 1 H NMR LA 400 MHz (Jeol) Assiut University.…”

Synthesis and Reaction of Novel Spiro Pyrimidine Derivatives

“…Electron deficient nature of pyrimidine ring facilitates the synthesis of large number of pyrimidine derivatives through nucleophilic aromatic substitution of suitable leaving groups. The halogens have been especially useful in this regard . Thus, compound 8 that reacts with sodium azide gave the corresponding tetrazolopyrimidine 10 presumably via the formation of azido form 9 .…”

“…In this manuscript, we use new methods in the synthesis of compounds derived thia‐tetraaza‐spir [4.5 deca‐2, 8‐dien‐7‐one derivative. To our knowledge, this is the second report on the synthesis of 4‐amino‐8‐[(pyridin‐4‐ylmethylene)‐amino]‐2 H ‐pyrimido [2, 1‐b] [1,3] thiazin‐6‐one and 7‐[(pyridin‐4‐ylmethylene)‐amino]‐4 H ‐tetrazolo [1, 5‐a]pyrimidin‐5‐one.…”