ChemInform Abstract: Synthesis and Biological Activity 1,2,4‐Triazinotriazinone Derivatives.

Abstract

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WITHDRAWN: Reactivity of 3-hydrazono-1, 2, 4-triazines towards various strong electrophiles - Synthesis of heteropolycyclic nitrogen systems Targets a review

“…The chemistry of polyfunctional 1,2, 4-triazines has proved to be very useful in the synthetic heteropolycyclic nitrogen systems ( Abdel-Rahman et al, 2010;Ibrahim et al, 2009;Ibrahim et al, 2008), as well as established in the field of pharmacological chemistry as anti AIDS and anti-cancer (Abdel-Rahman, 1991;Abdel-Rahman, 1992;Abdel-Rahman, et al, 1994;Abdel-Rahman et al, 1994;Abdel-Rahman et al, 1995;AbdelRahman et al, 1999;El-Gendy et al, 2001;El-Gendy et al, 2003;) and in the plant protection (AbdelRahman R. M., 2001). In additional used their as biocidal targets Abdel-Monem & Abdel-Rahman 2006).…”

Convenient Synthesis of New Boric Acid Catalyzed 1,2,4‐Triazolopyridinone Derivatives and an Investigation of their Optical Properties

“…1,2,4-Triazine derivatives are important classes of heterocyclic compounds which have various biological properties such as anticancer, muscle relaxant, hypnotic, anti-inflammatory, diuretic, and antihypertensive activities [1][2][3][4]. In particular, literature studies on 1,2,4-triazoles have shown that the fused 1,2,4-triazoles have a great potential as antifungal [5], antibactericidal [5,6], anxiolytic [7,8], anticonvulsant [9], or herbicidal [10] activities and can act as "antidepressant" reagents [11].…”

Fluorine Substituted 1,2,4-Triazinones as Potential Anti-HIV-1 and CDK2 Inhibitors

“…In addition, BX-1382BS (V) showed a significant activity as protein kinase inhibitor [26] and a cyanopyrimidine scaffold JNJ-17029259 (VI) is an oral inhibitor of VEGF-mediated signal transduction [27] (Figure 1). Recently a great deal of synthetic efforts has been spent on fluorinated uncondensed 1,2,4-triazines by our group searching for new anti-HIV and anticancer agents [28][29][30][31][32][33][34][35][36][37][38] (compounds A-F; Figure 2).…”