ChemInform Abstract: SYNTHESIS AND BIOLOGICAL PROPERTIES OF CHOLINE ESTERS OF AMINO ACIDS

Abstract

Die β‐Dimethylaminoethylester geschützter Glycine werden nach verschiedenen Methoden hergestellt.

Choline esters of N-substituted amino acids. IX. Synthesis and cholinergic properties of β-dimethylaminoethyl esters of N-substituted amino acids

“…The cholinergic properties of choline esters of the N-substituted ct-, 13-, 7-and e-amino acids were studied on a Rectus abdominus muscle of a Rana temporaria frog as described in [4].…”

“…An analysis of the reaction mixture of 2-(N-phthaloyl-13-alanyl)-l-oxybenzotriazole (IIIf) with DMAE 2 (1 : 2) performed by TLC (Silufol UV-254, chloroform-benzenemethanol, 9 : 1 : 1) showed that the "activated" amide IIIf is completely consumed within 45 rain. Such a high rate of the reaction between DMAE with III (as compared to that with p-nitrophenyl esters [3,4]) is quite expectable, since benzotriazole-l-oxy group exceeds the p-nitrophen0xy group 2 Besides the standard abbreviations recommended by the IUPAC-IUB Commission on biochemistry nomenclature [10, I 1] we use the following abbreviations: DMAE = 13-dimethylaminoethanol, 7-Abu = ~,-aminobutyric acid (GABA), ~-Aka = e-aminocaproic acid. …”