ChemInform Abstract: Synthesis and Biological Activity of N‐Alkyl Derivatives of Ibotenic Acid.

Abstract

Synthesis and Biological Activity of N-Alkyl Derivatives of IbotenicAcid.-The synthesis of the title ibotenic acid derivatives involves the bromination of derivative (I) to furnish compound (II), ester hydrolysis and amination-desulfonylation of the intermediary formed bromoibotenic acid. The interaction of the derivatives (IV) with stimulation receptors of the C.N.S. is studied in detail. -(DUMPIS, M. A.; BRAUNER-OSBORN, KH.; MADSEN, U.; PIOTROVSKII, L. B.; Khim.-Farm. Zh. 33 (1999) 1, 13-16; Inst. eksp. med. Ross. Akad. med. nauk, St. Petersburg, Russia; RU)