2015
DOI: 10.1002/chin.201522246
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ChemInform Abstract: Synthesis and Biological Activity of 10‐Aza‐narciclasine.

Abstract: Synthesis and Biological Activity of 10-Aza-narciclasine. -Title compound (VI) is synthesized starting from pyridine derivative (I) over 12 steps in an overall yield of 2.05%. The key steps are the halogen dance reaction of (II) and the intramolecular Heck reaction of imide (IV). Compound (VI) is found to have reasonable activity against several cancer cell lines. -(VSHYVENKO, S.; W'GIORGIS, Z.; WEBER, A.; NEVEROVA, N.; HEDBERG, B.; HUDLICKY*, T.; Adv. Synth. Catal. 357 (2015) 1, 83-87, http://dx.doi.org/10.10… Show more

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