ChemInform Abstract: Synthesis and Biophysical Properties of Constrained D‐Altritol Nucleic Acids (cANA).

Abstract

Synthesis and Biophysical Properties of Constrained D-Altritol Nucleic Acids (cANA). -Constrained altritol nucleotide derivatives (I) are incorporated into antisense oligonucleotides (ASO) in order to study how conformationally restricting the D-altritol backbone-containing ASO will affect their ability to form duplexes with RNA. -(MIGAWA*, M. T.; PRAKASH, T. P.; VASQUEZ, G.; SETH, P. P.; SWAYZE, E. E.; Org. Lett. 15 (2013) 17, 4316-4319, http://dx.